Dynamics of GABAρ2 receptors in retinal bipolar neurons and cerebellar astrocytes

Gustavo Martínez-Delgado, Daniel Reyes-Haro, Angeles E. Espino-Saldaña, Abraham Rosas-Arellano, Adriana Pétriz, Patricia Juárez-Mercado, Ricardo Miledi, Ataulfo Martínez-Torres

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Gamma-aminobutyric acid (GABA)q receptors are selectively targeted to the axon terminals of the retinal bipolar neurons. The traffic of a green fluorescent protein-tagged GABAq2 was examined in retinal bipolar neurons and cerebellar astrocytes. In bipolar neurons, time-lapse laser confocal microscopy revealed that the fluorescence emitted by GABAq2-green fluorescent protein accumulates first, in clusters, in the soma and is then distributed along the axon in at least two populations: one that remains relatively immobile and a second population of smaller clusters that moved constantly to and from the axon end. In astrocytes, the fluorescent clusters were relatively immobile and located mainly in the soma.

Original languageEnglish
Pages (from-to)4-9
Number of pages6
JournalNeuroReport
Volume22
Issue number1
DOIs
StatePublished - 5 Jan 2011
Externally publishedYes

Keywords

  • Axon targeting
  • Patch clamp
  • Voltage clamp
  • Xenopus oocytes

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