Dynamics of DNA Damage Recognition

Eleanore Seibert, Roman Osman, J. B.Alexander Ross

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Maintenance of the native DNA sequence and structure is essential for normal function and ultimately to survival. DNA damage can result from numerous external agents and from normal cellular processes. For example, ionizing radiation can induce single-and double-strand breaks, exposure to UV light can produce pyrimidine dimers, spontaneous depurination or enzyme-mediated base removal can produce abasic sites, and cytosine deamination can yield a non-native DNA base-uracil. These lesions produce structural and dynamic changes in DNA, which impair its function. In fact, failure to correctly repair DNA damage can result in mutations, cancer, and death. To minimize the detrimental effects of DNA damage, evolution has provided cells with DNA repair systems, each eliminating a different kind of DNA damage and restoring its normal function.

Original languageEnglish
Title of host publicationDNA Damage Recognition
PublisherCRC Press
Pages3-19
Number of pages17
ISBN (Electronic)9780849352683
ISBN (Print)9780824759612
DOIs
StatePublished - 1 Jan 2005

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