Dynamics of cardiac intracellular Ca2+ handling - From experiments to virtual cells

H. Zhang; D. Noble; M. Cannell; C. H. Orchard; M. Lancaster; S. A. Jones; M. R. Boyett; A. V. Holden; M. Saleet Jafri; E. A. Sobie; W. J. Lederer; S. S. Demir; A. Michailova; F. Delprincipe; M. Egger; E. Niggli; G. L. Smith; C. M. Loughrey; N. Macquaide; J. Dempster; A. W. Trafford

doi:10.1142/S0218127403008843

Dynamics of cardiac intracellular Ca²⁺ handling - From experiments to virtual cells

H. Zhang, D. Noble, M. Cannell, C. H. Orchard, M. Lancaster, S. A. Jones, M. R. Boyett, A. V. Holden, M. Saleet Jafri, E. A. Sobie, W. J. Lederer, S. S. Demir, A. Michailova, F. Delprincipe, M. Egger, E. Niggli, G. L. Smith, C. M. Loughrey, N. Macquaide, J. DempsterA. W. Trafford

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Intracellular cardiac Ca²⁺ handling involves interactions of numerous distinct cellular and macromolecular structures. Such interactions coordinate the complicated behaviors of individual processes into spatial and temporal coherent patterns of Ca²⁺ sparks, oscillations and traveling waves. Understanding the dynamical behaviors and functional roles of intracellular Ca²⁺ handling requires not only detailed experimental information about subcellular structures and dynamics, but also useful tools to integrate and analyze this information. This requires interactions between experimental and simulation results within a virtual cell.

Original language	English
Pages (from-to)	3535-3560
Number of pages	26
Journal	International Journal of Bifurcation and Chaos in Applied Sciences and Engineering
Volume	13
Issue number	12
DOIs	https://doi.org/10.1142/S0218127403008843
State	Published - Dec 2003
Externally published	Yes

Keywords

Calcium spark
Oscillation
Wave

Access to Document

10.1142/S0218127403008843

Cite this

Zhang, H., Noble, D., Cannell, M., Orchard, C. H., Lancaster, M., Jones, S. A., Boyett, M. R., Holden, A. V., Jafri, M. S., Sobie, E. A., Lederer, W. J., Demir, S. S., Michailova, A., Delprincipe, F., Egger, M., Niggli, E., Smith, G. L., Loughrey, C. M., Macquaide, N., ... Trafford, A. W. (2003). Dynamics of cardiac intracellular Ca²⁺ handling - From experiments to virtual cells. International Journal of Bifurcation and Chaos in Applied Sciences and Engineering, 13(12), 3535-3560. https://doi.org/10.1142/S0218127403008843

@article{30e0db9c28c8414d9f2247097c8aff57,

title = "Dynamics of cardiac intracellular Ca2+ handling - From experiments to virtual cells",

abstract = "Intracellular cardiac Ca2+ handling involves interactions of numerous distinct cellular and macromolecular structures. Such interactions coordinate the complicated behaviors of individual processes into spatial and temporal coherent patterns of Ca2+ sparks, oscillations and traveling waves. Understanding the dynamical behaviors and functional roles of intracellular Ca2+ handling requires not only detailed experimental information about subcellular structures and dynamics, but also useful tools to integrate and analyze this information. This requires interactions between experimental and simulation results within a virtual cell.",

keywords = "Calcium spark, Oscillation, Wave",

author = "H. Zhang and D. Noble and M. Cannell and Orchard, {C. H.} and M. Lancaster and Jones, {S. A.} and Boyett, {M. R.} and Holden, {A. V.} and Jafri, {M. Saleet} and Sobie, {E. A.} and Lederer, {W. J.} and Demir, {S. S.} and A. Michailova and F. Delprincipe and M. Egger and E. Niggli and Smith, {G. L.} and Loughrey, {C. M.} and N. Macquaide and J. Dempster and Trafford, {A. W.}",

year = "2003",

month = dec,

doi = "10.1142/S0218127403008843",

language = "English",

volume = "13",

pages = "3535--3560",

journal = "International Journal of Bifurcation and Chaos in Applied Sciences and Engineering",

issn = "0218-1274",

publisher = "World Scientific Publishing Co. Pte Ltd",

number = "12",

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Zhang, H, Noble, D, Cannell, M, Orchard, CH, Lancaster, M, Jones, SA, Boyett, MR, Holden, AV, Jafri, MS, Sobie, EA, Lederer, WJ, Demir, SS, Michailova, A, Delprincipe, F, Egger, M, Niggli, E, Smith, GL, Loughrey, CM, Macquaide, N, Dempster, J & Trafford, AW 2003, 'Dynamics of cardiac intracellular Ca²⁺ handling - From experiments to virtual cells', International Journal of Bifurcation and Chaos in Applied Sciences and Engineering, vol. 13, no. 12, pp. 3535-3560. https://doi.org/10.1142/S0218127403008843

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T1 - Dynamics of cardiac intracellular Ca2+ handling - From experiments to virtual cells

AU - Zhang, H.

AU - Noble, D.

AU - Cannell, M.

AU - Orchard, C. H.

AU - Lancaster, M.

AU - Jones, S. A.

AU - Boyett, M. R.

AU - Holden, A. V.

AU - Jafri, M. Saleet

AU - Sobie, E. A.

AU - Lederer, W. J.

AU - Demir, S. S.

AU - Michailova, A.

AU - Delprincipe, F.

AU - Egger, M.

AU - Niggli, E.

AU - Smith, G. L.

AU - Loughrey, C. M.

AU - Macquaide, N.

AU - Dempster, J.

AU - Trafford, A. W.

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AB - Intracellular cardiac Ca2+ handling involves interactions of numerous distinct cellular and macromolecular structures. Such interactions coordinate the complicated behaviors of individual processes into spatial and temporal coherent patterns of Ca2+ sparks, oscillations and traveling waves. Understanding the dynamical behaviors and functional roles of intracellular Ca2+ handling requires not only detailed experimental information about subcellular structures and dynamics, but also useful tools to integrate and analyze this information. This requires interactions between experimental and simulation results within a virtual cell.

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KW - Oscillation

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