Dynamic mapping of human cortical development during childhood through early adulthood

Nitin Gogtay, Jay N. Giedd, Leslie Lusk, Kiralee M. Hayashi, Deanna Greenstein, A. Catherine Vaituzis, Tom F. Nugent, David H. Herman, Liv S. Clasen, Arthur W. Toga, Judith L. Rapoport, Paul M. Thompson

Research output: Contribution to journalArticlepeer-review

3969 Scopus citations

Abstract

We report the dynamic anatomical sequence of human cortical gray matter development between the age of 4-21 years using quantitative four-dimensional maps and time-lapse sequences. Thirteen healthy children for whom anatomic brain MRI scans were obtained every 2 years, for 8-10 years, were studied. By using models of the cortical surface and sulcal landmarks and a statistical model for gray matter density, human cortical development could be visualized across the age range in a spatiotemporally detailed time-lapse sequence. The resulting resulting time-lapse "movies" reveal that (i) higher-order association cortices mature only after lower-order somatosensory and visual cortices, the functions of which they integrate, are developed, and (ii) phylogenetically older brain areas mature earlier than newer ones. Direct comparison with normal cortical development may help understanding of some neurodevelopmental disorders such as childhood-onset schizophrenia or autism.

Original languageEnglish
Pages (from-to)8174-8179
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume101
Issue number21
DOIs
StatePublished - 21 May 2004
Externally publishedYes

Fingerprint

Dive into the research topics of 'Dynamic mapping of human cortical development during childhood through early adulthood'. Together they form a unique fingerprint.

Cite this