Dynamic computed tomography of the lung: Regional ventilation measurements

D. Gur, B. P. Drayer, H. S. Borovetz, B. P. Griffith, R. L. Hardesty, S. K. Wolfson

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


The spatial resolution provided by computed tomography (CT) yields excellent anatomic specificity, and fast scanners are capable of the serial imaging necessary to monitor rapid changes in tracer concentration over time. In this study, sequential CT imaging defined the temporal changes of xenon concentration in peripheral lung tissue of a nonhuman primate and three sheep, both during and after xenon inhalation. Ventilation rate constants (K) in lung tissue with normal and impaired function were assessed and compared. Limitations and potential solutions involved in the evaluation of regional ventilation using xenon enhanced CT are discussed.

Original languageEnglish
Pages (from-to)749-753
Number of pages5
JournalJournal of Computer Assisted Tomography
Issue number6
StatePublished - Dec 1979
Externally publishedYes


  • Animal studies
  • Computed tomography
  • Lungs
  • Ventilation
  • Xenon


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