Dynamic and conformational switching in proteins

H. A. Scheraga, S. Rackovsky

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Using bioinformatic methods for treating protein dynamics, developed in earlier work, we study the relationship between sequence mobility and dynamics in proteins. It is shown that sequence mobility drives a transition between two dynamic regimes in proteins, and that the specific details of this transition differ qualitatively between α-helical proteins and those in other structural classes. We examine the possibility that conformational switching is related to dynamic switching, by considering a specific system of sequences which exhibit the switching phenomenon. It is shown that a relationship between dynamic and conformational switching is entirely plausible.

Original languageEnglish
Article numbere23411
Issue number10
StatePublished - Oct 2021
Externally publishedYes


  • conformational switching
  • protein dynamics
  • sequence mobility


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