Dynamic and conformational switching in proteins

H. A. Scheraga, S. Rackovsky

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Using bioinformatic methods for treating protein dynamics, developed in earlier work, we study the relationship between sequence mobility and dynamics in proteins. It is shown that sequence mobility drives a transition between two dynamic regimes in proteins, and that the specific details of this transition differ qualitatively between α-helical proteins and those in other structural classes. We examine the possibility that conformational switching is related to dynamic switching, by considering a specific system of sequences which exhibit the switching phenomenon. It is shown that a relationship between dynamic and conformational switching is entirely plausible.

Original languageEnglish
Article numbere23411
JournalBiopolymers
Volume112
Issue number10
DOIs
StatePublished - Oct 2021
Externally publishedYes

Keywords

  • conformational switching
  • protein dynamics
  • sequence mobility

Fingerprint

Dive into the research topics of 'Dynamic and conformational switching in proteins'. Together they form a unique fingerprint.

Cite this