TY - JOUR
T1 - Dual tracer resorption and apposition in a rat fracture model
AU - Castronovo, Frank P.
AU - Strauss, H. William
PY - 1988
Y1 - 1988
N2 - The simultaneous measurement of tracer resorption and apposition in a rat fracture model was accomplished with 99mTc labeled methylene diphosphonate (99mTc-MDP) and 125I labeled phenylphosphonic acid (125I-øPA), respectively. Loss of 125I-øPA from the fracture site showed a biexponential release pattern; I = 31% (t 1 2b = 2.0 d) and II = 69% (t 1 2b = 55.4 d). 99mTc MDP temporal apposition at the fracture site followed the law of allometric growth (y = bxk) with k = 7.75, 10 days post injury. The 125I-øPA loss differed significantly (P < 0.001) when compared to normal bone which exhibits a monoexponential release with a t 1 2b = 962 days. In the rat tibia fracture model investigated, bone apposition significantly (P < 0.001) dominates over bone resorption as a function of time. This overwhelming difference partially accounts for the healing process. The apposition-resorption comparison may be a useful index for following the course of skeletal pathology for a variety of model systems.
AB - The simultaneous measurement of tracer resorption and apposition in a rat fracture model was accomplished with 99mTc labeled methylene diphosphonate (99mTc-MDP) and 125I labeled phenylphosphonic acid (125I-øPA), respectively. Loss of 125I-øPA from the fracture site showed a biexponential release pattern; I = 31% (t 1 2b = 2.0 d) and II = 69% (t 1 2b = 55.4 d). 99mTc MDP temporal apposition at the fracture site followed the law of allometric growth (y = bxk) with k = 7.75, 10 days post injury. The 125I-øPA loss differed significantly (P < 0.001) when compared to normal bone which exhibits a monoexponential release with a t 1 2b = 962 days. In the rat tibia fracture model investigated, bone apposition significantly (P < 0.001) dominates over bone resorption as a function of time. This overwhelming difference partially accounts for the healing process. The apposition-resorption comparison may be a useful index for following the course of skeletal pathology for a variety of model systems.
UR - http://www.scopus.com/inward/record.url?scp=45549117790&partnerID=8YFLogxK
U2 - 10.1016/0883-2897(88)90086-4
DO - 10.1016/0883-2897(88)90086-4
M3 - Article
C2 - 3366620
AN - SCOPUS:45549117790
SN - 0883-2897
VL - 15
SP - 181-183,185
JO - Nuclear Medicine and Biology
JF - Nuclear Medicine and Biology
IS - 2
ER -