Dual-functional lipid-like nanoparticles for delivery of mRNA and MRI contrast agents

X. Luo; B. Li; X. Zhang; W. Zhao; A. Bratasz; B. Deng; D. W. McComb; Y. Dong

doi:10.1039/c6nr08496f

Dual-functional lipid-like nanoparticles for delivery of mRNA and MRI contrast agents

X. Luo
, B. Li
, X. Zhang
, W. Zhao
, A. Bratasz
, B. Deng
, D. W. McComb
, Y. Dong

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Multi-functional nanomaterials possess unique properties, facilitating both therapeutic and diagnostic applications among others. Herein, we developed dual-functional lipid-like nanoparticles for simultaneous delivery of mRNA and magnetic resonance imaging (MRI) contrast agents in order to express functional proteins and provide real-time visualization. TT3-Gd18 LLNs were identified as a lead formulation, which was able to encapsulate 91% of mRNA and 74% of Gd. This formulation showed a comparable or a slightly higher delivery efficiency of mRNA compared to the initial TT3 LLNs. Moreover, a strong MRI signal was observed in the cell pellets treated with TT3-Gd18 LLNs. More importantly, TT3-Gd18 LLNs demonstrated an efficient delivery of mRNA and Gd contrast agents in vivo.

Original language	English
Pages (from-to)	1575-1579
Number of pages	5
Journal	Nanoscale
Volume	9
Issue number	4
DOIs	https://doi.org/10.1039/c6nr08496f
State	Published - 28 Jan 2017
Externally published	Yes

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title = "Dual-functional lipid-like nanoparticles for delivery of mRNA and MRI contrast agents",

abstract = "Multi-functional nanomaterials possess unique properties, facilitating both therapeutic and diagnostic applications among others. Herein, we developed dual-functional lipid-like nanoparticles for simultaneous delivery of mRNA and magnetic resonance imaging (MRI) contrast agents in order to express functional proteins and provide real-time visualization. TT3-Gd18 LLNs were identified as a lead formulation, which was able to encapsulate 91\% of mRNA and 74\% of Gd. This formulation showed a comparable or a slightly higher delivery efficiency of mRNA compared to the initial TT3 LLNs. Moreover, a strong MRI signal was observed in the cell pellets treated with TT3-Gd18 LLNs. More importantly, TT3-Gd18 LLNs demonstrated an efficient delivery of mRNA and Gd contrast agents in vivo.",

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AU - Luo, X.

AU - Li, B.

AU - Zhang, X.

AU - Zhao, W.

AU - Bratasz, A.

AU - Deng, B.

AU - McComb, D. W.

AU - Dong, Y.

PY - 2017/1/28

Y1 - 2017/1/28

N2 - Multi-functional nanomaterials possess unique properties, facilitating both therapeutic and diagnostic applications among others. Herein, we developed dual-functional lipid-like nanoparticles for simultaneous delivery of mRNA and magnetic resonance imaging (MRI) contrast agents in order to express functional proteins and provide real-time visualization. TT3-Gd18 LLNs were identified as a lead formulation, which was able to encapsulate 91% of mRNA and 74% of Gd. This formulation showed a comparable or a slightly higher delivery efficiency of mRNA compared to the initial TT3 LLNs. Moreover, a strong MRI signal was observed in the cell pellets treated with TT3-Gd18 LLNs. More importantly, TT3-Gd18 LLNs demonstrated an efficient delivery of mRNA and Gd contrast agents in vivo.

AB - Multi-functional nanomaterials possess unique properties, facilitating both therapeutic and diagnostic applications among others. Herein, we developed dual-functional lipid-like nanoparticles for simultaneous delivery of mRNA and magnetic resonance imaging (MRI) contrast agents in order to express functional proteins and provide real-time visualization. TT3-Gd18 LLNs were identified as a lead formulation, which was able to encapsulate 91% of mRNA and 74% of Gd. This formulation showed a comparable or a slightly higher delivery efficiency of mRNA compared to the initial TT3 LLNs. Moreover, a strong MRI signal was observed in the cell pellets treated with TT3-Gd18 LLNs. More importantly, TT3-Gd18 LLNs demonstrated an efficient delivery of mRNA and Gd contrast agents in vivo.

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Dual-functional lipid-like nanoparticles for delivery of mRNA and MRI contrast agents

Abstract

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