Drugs affecting the cholinergic system in the intact mammalian eye. II. Cholinesterase inhibitors

S. Maayani; G. Treister; M. Sokolovsky

doi:10.1159/000264897

Drugs affecting the cholinergic system in the intact mammalian eye. II. Cholinesterase inhibitors

S. Maayani, G. Treister, M. Sokolovsky

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of concentration and pH on the miotic activity of four cholinesterase inhibitors were studied in the intact mouse eye: while eserine (physostigmine) behaved in a dose-dependent manner, the other 3 drugs - phospholine-iodide, tacrine and diisopropylfluorophosphate showed no dose dependency in the concentration range investigated. On the other hand, the latter 2 inhibitors exhibited a marked pH dependency. The different structural features of these drugs, which may contribute to the observed difference in miotic pattern are presented and discussed.

Original language	English
Pages (from-to)	289-295
Number of pages	7
Journal	Ophthalmic Research
Volume	9
Issue number	5
DOIs	https://doi.org/10.1159/000264897
State	Published - 1977
Externally published	Yes

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title = "Drugs affecting the cholinergic system in the intact mammalian eye. II. Cholinesterase inhibitors",

abstract = "The effects of concentration and pH on the miotic activity of four cholinesterase inhibitors were studied in the intact mouse eye: while eserine (physostigmine) behaved in a dose-dependent manner, the other 3 drugs - phospholine-iodide, tacrine and diisopropylfluorophosphate showed no dose dependency in the concentration range investigated. On the other hand, the latter 2 inhibitors exhibited a marked pH dependency. The different structural features of these drugs, which may contribute to the observed difference in miotic pattern are presented and discussed.",

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N2 - The effects of concentration and pH on the miotic activity of four cholinesterase inhibitors were studied in the intact mouse eye: while eserine (physostigmine) behaved in a dose-dependent manner, the other 3 drugs - phospholine-iodide, tacrine and diisopropylfluorophosphate showed no dose dependency in the concentration range investigated. On the other hand, the latter 2 inhibitors exhibited a marked pH dependency. The different structural features of these drugs, which may contribute to the observed difference in miotic pattern are presented and discussed.

AB - The effects of concentration and pH on the miotic activity of four cholinesterase inhibitors were studied in the intact mouse eye: while eserine (physostigmine) behaved in a dose-dependent manner, the other 3 drugs - phospholine-iodide, tacrine and diisopropylfluorophosphate showed no dose dependency in the concentration range investigated. On the other hand, the latter 2 inhibitors exhibited a marked pH dependency. The different structural features of these drugs, which may contribute to the observed difference in miotic pattern are presented and discussed.

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Drugs affecting the cholinergic system in the intact mammalian eye. II. Cholinesterase inhibitors

Abstract

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