Drug solubilizers to aid pharmacologists: Amorphous cyclodextrin derivatives

Josef Pitha, Tetsumi Irie, Pamela B. Sklar, Jeffrey S. Nye

Research output: Contribution to journalArticlepeer-review

226 Scopus citations

Abstract

Conversion of crystalline α-, β-, or γ-cyclodextrins into amorphous mixtures of water soluble derivatives yields non-toxic solubilizers which dissolve drugs through the formation of inclusion complexes. From these types of compounds 2-hydroxypropyl ethers of cyclodextrins have presently been investigated and the ranges for the safe use in working with (a) receptor binding assays on membrane preparations, (b) cells in vitro, and (c) parenteral use in mice were established for these compounds. The drugs which were investigated were dissolved in amounts linearly proportionate to the concentration of the solubilizers used and did not precipitate upon dilution by aqueous media. These solubilizers may considerably facilitate pharmacological evaluation of new, water insoluble potential drugs.

Original languageEnglish
Pages (from-to)493-502
Number of pages10
JournalLife Sciences
Volume43
Issue number6
DOIs
StatePublished - 1988
Externally publishedYes

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