Drug-Resistant Tuberculosis: Challenges and Progress

Sebastian G. Kurz, Jennifer J. Furin, Charles M. Bark

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


Antimicrobial resistance is a natural evolutionary process, which in the case of Mycobacterium tuberculosis is based on spontaneous chromosomal mutations, meaning that well-designed combination drug regimens provided under supervised therapy will prevent the emergence of drug-resistant strains. Unfortunately, limited resources, poverty, and neglect have led to the emergence of drug-resistant tuberculosis throughout the world. The international community has responded with financial and scientific support, leading to new rapid diagnostics, new drugs and regimens in advanced clinical development, and an increasingly sophisticated understanding of resistance mechanisms and their application to all aspects of TB control and treatment.

Original languageEnglish
Pages (from-to)509-522
Number of pages14
JournalInfectious Disease Clinics of North America
Issue number2
StatePublished - 1 Jun 2016
Externally publishedYes


  • Antimicrobial resistance
  • Drug-resistant tuberculosis
  • Mycobacterium tuberculosis


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