Drug-Induced Liver Injury: Understanding the Different Immune-Mediated Phenotypes and Clinical Management

Ben L. Da; Gil Ben-Yakov; David Kleiner; Christopher Koh

doi:10.1007/s11901-018-0407-9

Drug-Induced Liver Injury: Understanding the Different Immune-Mediated Phenotypes and Clinical Management

Ben L. Da
, Gil Ben-Yakov
, David Kleiner
, Christopher Koh

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Purpose of Review: The aim of this manuscript is to review two immune-mediated drug-induced liver injury (DILI) phenotypes, immune-allergic DILI (IA-DILI) and DILI with autoimmune hepatitis features (DILI-AIH), which are poorly defined and can lead to significant morbidity and mortality. Recent Findings: Recent information on this topic improves the understanding of IA-DILI and DILI-AIH regarding risk factors, associated medications, clinical presentations, histopathologic findings, and management strategies. Summary: Although the pathogenesis and specific mechanisms remain elusive, clinical and pathological advancements in our understanding of IA-DILI and DILI-AIH have provided clinicians with added tools for the diagnosis and management of these diseases. Further studies are needed to improve our understanding of immune-mediated DILI.

Original language	English
Pages (from-to)	235-244
Number of pages	10
Journal	Current Hepatology Reports
Volume	17
Issue number	3
DOIs	https://doi.org/10.1007/s11901-018-0407-9
State	Published - Sep 2018
Externally published	Yes

Keywords

Chemical and drug-induced liver injury
Drug-induced abnormalities
Drug-induced liver injury
Hepatitis
Hepatitis, autoimmune
Hepatitis, drug-induced

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10.1007/s11901-018-0407-9

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title = "Drug-Induced Liver Injury: Understanding the Different Immune-Mediated Phenotypes and Clinical Management",

abstract = "Purpose of Review: The aim of this manuscript is to review two immune-mediated drug-induced liver injury (DILI) phenotypes, immune-allergic DILI (IA-DILI) and DILI with autoimmune hepatitis features (DILI-AIH), which are poorly defined and can lead to significant morbidity and mortality. Recent Findings: Recent information on this topic improves the understanding of IA-DILI and DILI-AIH regarding risk factors, associated medications, clinical presentations, histopathologic findings, and management strategies. Summary: Although the pathogenesis and specific mechanisms remain elusive, clinical and pathological advancements in our understanding of IA-DILI and DILI-AIH have provided clinicians with added tools for the diagnosis and management of these diseases. Further studies are needed to improve our understanding of immune-mediated DILI.",

keywords = "Chemical and drug-induced liver injury, Drug-induced abnormalities, Drug-induced liver injury, Hepatitis, Hepatitis, autoimmune, Hepatitis, drug-induced",

author = "Da, \{Ben L.\} and Gil Ben-Yakov and David Kleiner and Christopher Koh",

note = "Publisher Copyright: {\textcopyright} This is a U.S. government work and its text is not subject to copyright protection in the United States; however, its text may be subject to foreign copyright protection 2018.",

year = "2018",

month = sep,

doi = "10.1007/s11901-018-0407-9",

language = "English",

volume = "17",

pages = "235--244",

journal = "Current Hepatology Reports",

issn = "2195-9595",

publisher = "Springer Nature",

number = "3",

}

TY - JOUR

T1 - Drug-Induced Liver Injury

T2 - Understanding the Different Immune-Mediated Phenotypes and Clinical Management

AU - Da, Ben L.

AU - Ben-Yakov, Gil

AU - Kleiner, David

AU - Koh, Christopher

N1 - Publisher Copyright: © This is a U.S. government work and its text is not subject to copyright protection in the United States; however, its text may be subject to foreign copyright protection 2018.

PY - 2018/9

Y1 - 2018/9

N2 - Purpose of Review: The aim of this manuscript is to review two immune-mediated drug-induced liver injury (DILI) phenotypes, immune-allergic DILI (IA-DILI) and DILI with autoimmune hepatitis features (DILI-AIH), which are poorly defined and can lead to significant morbidity and mortality. Recent Findings: Recent information on this topic improves the understanding of IA-DILI and DILI-AIH regarding risk factors, associated medications, clinical presentations, histopathologic findings, and management strategies. Summary: Although the pathogenesis and specific mechanisms remain elusive, clinical and pathological advancements in our understanding of IA-DILI and DILI-AIH have provided clinicians with added tools for the diagnosis and management of these diseases. Further studies are needed to improve our understanding of immune-mediated DILI.

AB - Purpose of Review: The aim of this manuscript is to review two immune-mediated drug-induced liver injury (DILI) phenotypes, immune-allergic DILI (IA-DILI) and DILI with autoimmune hepatitis features (DILI-AIH), which are poorly defined and can lead to significant morbidity and mortality. Recent Findings: Recent information on this topic improves the understanding of IA-DILI and DILI-AIH regarding risk factors, associated medications, clinical presentations, histopathologic findings, and management strategies. Summary: Although the pathogenesis and specific mechanisms remain elusive, clinical and pathological advancements in our understanding of IA-DILI and DILI-AIH have provided clinicians with added tools for the diagnosis and management of these diseases. Further studies are needed to improve our understanding of immune-mediated DILI.

KW - Chemical and drug-induced liver injury

KW - Drug-induced abnormalities

KW - Drug-induced liver injury

KW - Hepatitis

KW - Hepatitis, autoimmune

KW - Hepatitis, drug-induced

UR - https://www.scopus.com/pages/publications/85138161720

U2 - 10.1007/s11901-018-0407-9

DO - 10.1007/s11901-018-0407-9

M3 - Article

AN - SCOPUS:85138161720

SN - 2195-9595

VL - 17

SP - 235

EP - 244

JO - Current Hepatology Reports

JF - Current Hepatology Reports

IS - 3

ER -

Drug-Induced Liver Injury: Understanding the Different Immune-Mediated Phenotypes and Clinical Management

Abstract

Keywords

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