TY - JOUR
T1 - Drug-Induced Liver Injury
T2 - Understanding the Different Immune-Mediated Phenotypes and Clinical Management
AU - Da, Ben L.
AU - Ben-Yakov, Gil
AU - Kleiner, David
AU - Koh, Christopher
N1 - Publisher Copyright:
© This is a U.S. government work and its text is not subject to copyright protection in the United States; however, its text may be subject to foreign copyright protection 2018.
PY - 2018/9
Y1 - 2018/9
N2 - Purpose of Review: The aim of this manuscript is to review two immune-mediated drug-induced liver injury (DILI) phenotypes, immune-allergic DILI (IA-DILI) and DILI with autoimmune hepatitis features (DILI-AIH), which are poorly defined and can lead to significant morbidity and mortality. Recent Findings: Recent information on this topic improves the understanding of IA-DILI and DILI-AIH regarding risk factors, associated medications, clinical presentations, histopathologic findings, and management strategies. Summary: Although the pathogenesis and specific mechanisms remain elusive, clinical and pathological advancements in our understanding of IA-DILI and DILI-AIH have provided clinicians with added tools for the diagnosis and management of these diseases. Further studies are needed to improve our understanding of immune-mediated DILI.
AB - Purpose of Review: The aim of this manuscript is to review two immune-mediated drug-induced liver injury (DILI) phenotypes, immune-allergic DILI (IA-DILI) and DILI with autoimmune hepatitis features (DILI-AIH), which are poorly defined and can lead to significant morbidity and mortality. Recent Findings: Recent information on this topic improves the understanding of IA-DILI and DILI-AIH regarding risk factors, associated medications, clinical presentations, histopathologic findings, and management strategies. Summary: Although the pathogenesis and specific mechanisms remain elusive, clinical and pathological advancements in our understanding of IA-DILI and DILI-AIH have provided clinicians with added tools for the diagnosis and management of these diseases. Further studies are needed to improve our understanding of immune-mediated DILI.
KW - Chemical and drug-induced liver injury
KW - Drug-induced abnormalities
KW - Drug-induced liver injury
KW - Hepatitis
KW - Hepatitis, autoimmune
KW - Hepatitis, drug-induced
UR - https://www.scopus.com/pages/publications/85138161720
U2 - 10.1007/s11901-018-0407-9
DO - 10.1007/s11901-018-0407-9
M3 - Article
AN - SCOPUS:85138161720
SN - 1540-3416
VL - 17
SP - 235
EP - 244
JO - Current Hepatology Reports
JF - Current Hepatology Reports
IS - 3
ER -