Drug-induced liver injury: Metabolic and genetic basis

Shu Jie Wang, Pei Wang, Xiao Tian Li, Li Rong Zhang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Drug-induced liver injur ( Dili) is a significant reason of acute liver failure ami is the main cause of therapeutic drugs withdrawal from the market. Multiple mechanisms ran culminate in Dili, hut metabolism and genetics play distinct roles in this process. This review will cover papers we consider have addressed these mechanisms of Dili in commonly used medications for adults, and discuss the hot issues. The aim is lo generate discussion about the potential clinical significance among these researchs and point out the key areas for further study of DILL.

Original languageEnglish
Pages (from-to)898-902
Number of pages5
JournalChinese Pharmacological Bulletin
Volume32
Issue number7
DOIs
StatePublished - Jul 2016
Externally publishedYes

Keywords

  • CYP450
  • Dili
  • Genetics
  • Hepatotoxicity
  • HLA
  • Metabolism

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