Drug-induced liver injury: Metabolic and genetic basis

Shu Jie Wang; Pei Wang; Xiao Tian Li; Li Rong Zhang

doi:10.3969/j.issn.1001-1978.2016.07.003

Drug-induced liver injury: Metabolic and genetic basis

Shu Jie Wang, Pei Wang, Xiao Tian Li, Li Rong Zhang

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Drug-induced liver injur ( Dili) is a significant reason of acute liver failure ami is the main cause of therapeutic drugs withdrawal from the market. Multiple mechanisms ran culminate in Dili, hut metabolism and genetics play distinct roles in this process. This review will cover papers we consider have addressed these mechanisms of Dili in commonly used medications for adults, and discuss the hot issues. The aim is lo generate discussion about the potential clinical significance among these researchs and point out the key areas for further study of DILL.

Original language	English
Pages (from-to)	898-902
Number of pages	5
Journal	Chinese Pharmacological Bulletin
Volume	32
Issue number	7
DOIs	https://doi.org/10.3969/j.issn.1001-1978.2016.07.003
State	Published - Jul 2016
Externally published	Yes

Keywords

CYP450
Dili
Genetics
Hepatotoxicity
HLA
Metabolism

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10.3969/j.issn.1001-1978.2016.07.003

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title = "Drug-induced liver injury: Metabolic and genetic basis",

abstract = "Drug-induced liver injur ( Dili) is a significant reason of acute liver failure ami is the main cause of therapeutic drugs withdrawal from the market. Multiple mechanisms ran culminate in Dili, hut metabolism and genetics play distinct roles in this process. This review will cover papers we consider have addressed these mechanisms of Dili in commonly used medications for adults, and discuss the hot issues. The aim is lo generate discussion about the potential clinical significance among these researchs and point out the key areas for further study of DILL.",

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author = "Wang, {Shu Jie} and Pei Wang and Li, {Xiao Tian} and Zhang, {Li Rong}",

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AB - Drug-induced liver injur ( Dili) is a significant reason of acute liver failure ami is the main cause of therapeutic drugs withdrawal from the market. Multiple mechanisms ran culminate in Dili, hut metabolism and genetics play distinct roles in this process. This review will cover papers we consider have addressed these mechanisms of Dili in commonly used medications for adults, and discuss the hot issues. The aim is lo generate discussion about the potential clinical significance among these researchs and point out the key areas for further study of DILL.

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KW - Genetics

KW - Hepatotoxicity

KW - HLA

KW - Metabolism

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Drug-induced liver injury: Metabolic and genetic basis

Abstract

Keywords

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