TY - JOUR
T1 - Drug-induced "arousal" and the effectiveness of CS exposure in the reinstatement of memory
AU - Haroutunian, Vahram
AU - Riccio, David C.
N1 - Funding Information:
Several studies have demonstrated that the relatively rapid memory loss occurring in immature rats can be attenuated by certain types of experience during the retention interval. Campbell and Jaynes (1966) reported initially that periodic exposure to an abbreviated portion of the original Pavlovian conditioning session served to maintain retention of fear in weanling rats. This phenomenon of improved retention, or "reinstatement," has attracted interest as a way of examining the ontogeny of memory processes. What, for example, are the necessary and/or sufficient conditions for obtaining reinstatement? One approach to this question has been to examine the contribution of the separate components of the original Pavlovian conditioning. Presentation of the UCS alone (Haroutunian & Riccio, 1977) as well as re-pairing the CS and UCS during reinstatement (e.g., Campbell & Jaynes, 1966; Silvestri, Rohrbaugh, & Riccio, 1970) enhances retention. Evidence that exposure to CS alone can serve as a reinstatement is more equivocal: While brief 1 Now at Department of Psychology, Princeton University, Princeton, N.J. 08540. 2 This research was supported in part by NIMH Grant MH 30223. Requests for reprints should be addressed to Dr. David C. Riccio, Psychology Department, Kent State University, Kent, Ohio 44242.
PY - 1979/5
Y1 - 1979/5
N2 - Previous research has shown that the rapid retention loss in immature rats can be attenuated by various types of reminder episodes. Two experiments here examined the role of arousal in reinstating conditioned fear in young rats. The general paradigm consisted of Pavlovian fear conditioning at 21 days of age, a reinstatement treatment 1 week later, and a retention test at 35 days of age. In Experiment 1, exogenous ACTH in conjunction with fear cues, but not ACTH or cues alone, enhanced later retention. An ancillary experiment found no evidence for a similar reinstatement effect when either strychnine or amphetamine was employed. These results suggest that mimicking the training state during reinstatement may be more important than central nervous system arousal per se.
AB - Previous research has shown that the rapid retention loss in immature rats can be attenuated by various types of reminder episodes. Two experiments here examined the role of arousal in reinstating conditioned fear in young rats. The general paradigm consisted of Pavlovian fear conditioning at 21 days of age, a reinstatement treatment 1 week later, and a retention test at 35 days of age. In Experiment 1, exogenous ACTH in conjunction with fear cues, but not ACTH or cues alone, enhanced later retention. An ancillary experiment found no evidence for a similar reinstatement effect when either strychnine or amphetamine was employed. These results suggest that mimicking the training state during reinstatement may be more important than central nervous system arousal per se.
UR - https://www.scopus.com/pages/publications/0018609196
U2 - 10.1016/S0163-1047(79)92959-5
DO - 10.1016/S0163-1047(79)92959-5
M3 - Article
C2 - 224855
AN - SCOPUS:0018609196
SN - 0163-1047
VL - 26
SP - 115
EP - 120
JO - Behavioral and Neural Biology
JF - Behavioral and Neural Biology
IS - 1
ER -