Drug-induced "arousal" and the effectiveness of CS exposure in the reinstatement of memory

Vahram Haroutunian, David C. Riccio

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Previous research has shown that the rapid retention loss in immature rats can be attenuated by various types of reminder episodes. Two experiments here examined the role of arousal in reinstating conditioned fear in young rats. The general paradigm consisted of Pavlovian fear conditioning at 21 days of age, a reinstatement treatment 1 week later, and a retention test at 35 days of age. In Experiment 1, exogenous ACTH in conjunction with fear cues, but not ACTH or cues alone, enhanced later retention. An ancillary experiment found no evidence for a similar reinstatement effect when either strychnine or amphetamine was employed. These results suggest that mimicking the training state during reinstatement may be more important than central nervous system arousal per se.

Original languageEnglish
Pages (from-to)115-120
Number of pages6
JournalBehavioral and Neural Biology
Issue number1
StatePublished - May 1979
Externally publishedYes


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