Drug delivery strategies for cathepsin inhibitors in joint diseases

Dong Wang, Dieter Brömme

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Cathepsins play important roles in the development of joint and bone diseases such as osteoporosis, rheumatoid arthritis (RA) and osteoarthritis (OA). Cathepsin inhibitors are presently in development and clinical testing for use as novel disease-modifying drugs for the improved treatment of osteoporosis. They may also be applicable for the treatment of joint diseases. However, some barriers still hamper their clinical applications in these indications. Based on pathophysiological features of RA and OA, the authors discuss six potential drug delivery strategies for the effective delivery of cathepsin inhibitors or other antiarthritic drugs to the arthritic joint tissue. Successful application of these strategies may significantly contribute to a more effective and safe treatment of RA and OA.

Original languageEnglish
Pages (from-to)1015-1028
Number of pages14
JournalExpert Opinion on Drug Delivery
Issue number6
StatePublished - Nov 2005
Externally publishedYes


  • Cartilage
  • Cathepsin
  • Drug delivery
  • Inhibitor
  • Joint
  • Osteoarthritis
  • Osteoporosis
  • Rheumatoid arthritis
  • Subchondral bone


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