Drug-associated reversible granulomatous T cell dyscrasia: A distinct subset of the interstitial granulomatous drug reaction

Cynthia M. Magro, Andres E. Cruz-Inigo, Henry Votava, Michael Jacobs, David Wolfe, A. Neil Crowson

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Background: A cutaneous T-cell infiltrate exhibiting cytologic and architectural atypia, an aberrant phenotypic profile and clonal restriction would fall under the rubric of a T-cell dyscrasia. Although such an infiltrate could represent a lymphoma, this constellation of findings can also be seen in drug-associated pseudolymphoma. Methods: In 2001, two of the authors (CMM and AEC) proposed the term reversible T-cell dyscrasia to describe atypical T-lymphocytic infiltrates that manifest a light microscopic, phenotypic and molecular profile that closely parallels cutaneous T-cell lymphoma but regress when the causal drug is withdrawn. Results: Herein we report our 10 cases of drug-associated pseudolymphoma resembling granulomatous mycosis fungoides. Conclusions: We term this reaction pattern drug-associated reversible granulomatous T-cell dyscrasia and consider it a distinct subset of the interstitial granulomatous drug reaction.

Original languageEnglish
Pages (from-to)96-111
Number of pages16
JournalJournal of Cutaneous Pathology
Volume37
Issue numberSUPPL. 1
DOIs
StatePublished - 2010
Externally publishedYes

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