TY - JOUR
T1 - Drug-associated reversible granulomatous T cell dyscrasia
T2 - A distinct subset of the interstitial granulomatous drug reaction
AU - Magro, Cynthia M.
AU - Cruz-Inigo, Andres E.
AU - Votava, Henry
AU - Jacobs, Michael
AU - Wolfe, David
AU - Crowson, A. Neil
PY - 2010
Y1 - 2010
N2 - Background: A cutaneous T-cell infiltrate exhibiting cytologic and architectural atypia, an aberrant phenotypic profile and clonal restriction would fall under the rubric of a T-cell dyscrasia. Although such an infiltrate could represent a lymphoma, this constellation of findings can also be seen in drug-associated pseudolymphoma. Methods: In 2001, two of the authors (CMM and AEC) proposed the term reversible T-cell dyscrasia to describe atypical T-lymphocytic infiltrates that manifest a light microscopic, phenotypic and molecular profile that closely parallels cutaneous T-cell lymphoma but regress when the causal drug is withdrawn. Results: Herein we report our 10 cases of drug-associated pseudolymphoma resembling granulomatous mycosis fungoides. Conclusions: We term this reaction pattern drug-associated reversible granulomatous T-cell dyscrasia and consider it a distinct subset of the interstitial granulomatous drug reaction.
AB - Background: A cutaneous T-cell infiltrate exhibiting cytologic and architectural atypia, an aberrant phenotypic profile and clonal restriction would fall under the rubric of a T-cell dyscrasia. Although such an infiltrate could represent a lymphoma, this constellation of findings can also be seen in drug-associated pseudolymphoma. Methods: In 2001, two of the authors (CMM and AEC) proposed the term reversible T-cell dyscrasia to describe atypical T-lymphocytic infiltrates that manifest a light microscopic, phenotypic and molecular profile that closely parallels cutaneous T-cell lymphoma but regress when the causal drug is withdrawn. Results: Herein we report our 10 cases of drug-associated pseudolymphoma resembling granulomatous mycosis fungoides. Conclusions: We term this reaction pattern drug-associated reversible granulomatous T-cell dyscrasia and consider it a distinct subset of the interstitial granulomatous drug reaction.
UR - http://www.scopus.com/inward/record.url?scp=77949843617&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0560.2010.01518.x
DO - 10.1111/j.1600-0560.2010.01518.x
M3 - Article
C2 - 20482682
AN - SCOPUS:77949843617
SN - 0303-6987
VL - 37
SP - 96
EP - 111
JO - Journal of Cutaneous Pathology
JF - Journal of Cutaneous Pathology
IS - SUPPL. 1
ER -