TY - JOUR
T1 - Drosophila models for cancer research
AU - Vidal, Marcos
AU - Cagan, Ross L.
N1 - Funding Information:
MV and RLC are supported by R01-CA109730, R01-CA084309, and R01-EY011495 from the National Institutes of Health. We apologize to our colleagues whose work was not cited, for space considerations.
PY - 2006/2
Y1 - 2006/2
N2 - Drosophila is a model system for cancer research. Investigation with fruit flies has facilitated a number of important recent discoveries in the field: the hippo signaling pathway, which coordinates cell proliferation and death to achieve normal tissue size; 'social' behaviors of cells, including cell competition and apoptosis-induced compensatory proliferation, that help ensure normal tissue size; and a growing understanding of how oncogenes and tumor suppressors cooperate to achieve tumor growth and metastasis in situ. In the future, Drosophila models can be extended beyond basic research in the search for human therapeutics.
AB - Drosophila is a model system for cancer research. Investigation with fruit flies has facilitated a number of important recent discoveries in the field: the hippo signaling pathway, which coordinates cell proliferation and death to achieve normal tissue size; 'social' behaviors of cells, including cell competition and apoptosis-induced compensatory proliferation, that help ensure normal tissue size; and a growing understanding of how oncogenes and tumor suppressors cooperate to achieve tumor growth and metastasis in situ. In the future, Drosophila models can be extended beyond basic research in the search for human therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=30644469503&partnerID=8YFLogxK
U2 - 10.1016/j.gde.2005.12.004
DO - 10.1016/j.gde.2005.12.004
M3 - Review article
C2 - 16359857
AN - SCOPUS:30644469503
SN - 0959-437X
VL - 16
SP - 10
EP - 16
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 1
ER -