Drosophila Jun mediates Ras-dependent photoreceptor determination

Dirk Bohmann, Michael C. Ellis, Lena M. Staszewski, Marek Mlodzik

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

The expression of the D. melanogaster transcription factor Jun in the eye imaginal disc correlates temporally and spatially with the determination of neuronal photoreceptor fate. Expression of dominant negative forms of Jun in photoreceptor precursor cells results in dose-dependent loss of photoreceptors in the adult fly. Conversely, localized overexpression of Jun in the eye imaginal disc can induce the differentiation of additional photoreceptor cells. Furthermore, the transformation of nonneuronal cone cells into R7 neurons elicited by constitutively active forms of sevenless, Ras1, Raf, and MAP kinase is relieved in the presence of Jun mutants. These results demonstrate a requirement of Jun downstream of the sevenless/ras signaling pathway for neuronal development in the Drosophila eye.

Original languageEnglish
Pages (from-to)973-986
Number of pages14
JournalCell
Volume78
Issue number6
DOIs
StatePublished - 23 Sep 1994
Externally publishedYes

Fingerprint

Dive into the research topics of 'Drosophila Jun mediates Ras-dependent photoreceptor determination'. Together they form a unique fingerprint.

Cite this