Drosophila at the intersection of infection, inflammation, and cancer

Erdem Bangi

Research output: Contribution to journalShort surveypeer-review

26 Scopus citations

Abstract

Recent studies show that both cellular and humoral aspects of innate immunity play important roles during tumor progression. These interactions have traditionally been explored in vertebrate model systems. In recent years, Drosophila has emerged as a genetically tractable model system for studying key aspects of tumorigenesis including proliferation, invasion, and metastasis. The absence of adaptive immunity in Drosophila provides a unique opportunity to study the interactions between innate immune system and cancer in different genetic contexts. In this review, I discuss recent advances made by using Drosophila models of cancer to study the role of innate immune pathways Toll/Imd, JNK, and JAK-STAT, microbial infection and inflammation during tumor progression.

Original languageEnglish
Article number00103
JournalFrontiers in Cellular and Infection Microbiology
Volume3
Issue numberDEC
DOIs
StatePublished - 2013

Keywords

  • Cancer
  • Drosophila
  • Infection
  • Inflammation
  • Innate immune response

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