Doxorubicin-induced skin ulcer in the piglet

T. Okano; T. Ohnuma; A. Efremidis; J. F. Holland

Doxorubicin-induced skin ulcer in the piglet

T. Okano
, T. Ohnuma
, A. Efremidis
, J. F. Holland

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Skin ulceration produced by inadvertently extravasated doxorubicin is characterized by a prolonged course accompanied by severe morbidity, and it has proven to be notoriously difficult to treat. In attempts to identify possible antidotes, 11 different pharmacologic agents were tested using piglets because their skin is anatomically similar to that of man. Among the agents studied, topical implication of DMSO daily for 7 days tended to decrease the maximal diameter and accelerate healing of skin ulcers produced by intradermal doxorubicin. α-Tocopherol appeared to worsen the ulceration. None of the 11 agents studied prevented the development of ulcerations completely.

Original language	English
Pages (from-to)	1075-1078
Number of pages	4
Journal	Cancer Treatment Reports
Volume	67
Issue number	12
State	Published - 1983

Cite this

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title = "Doxorubicin-induced skin ulcer in the piglet",

abstract = "Skin ulceration produced by inadvertently extravasated doxorubicin is characterized by a prolonged course accompanied by severe morbidity, and it has proven to be notoriously difficult to treat. In attempts to identify possible antidotes, 11 different pharmacologic agents were tested using piglets because their skin is anatomically similar to that of man. Among the agents studied, topical implication of DMSO daily for 7 days tended to decrease the maximal diameter and accelerate healing of skin ulcers produced by intradermal doxorubicin. α-Tocopherol appeared to worsen the ulceration. None of the 11 agents studied prevented the development of ulcerations completely.",

author = "T. Okano and T. Ohnuma and A. Efremidis and Holland, \{J. F.\}",

year = "1983",

language = "English",

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AU - Okano, T.

AU - Ohnuma, T.

AU - Efremidis, A.

AU - Holland, J. F.

PY - 1983

Y1 - 1983

N2 - Skin ulceration produced by inadvertently extravasated doxorubicin is characterized by a prolonged course accompanied by severe morbidity, and it has proven to be notoriously difficult to treat. In attempts to identify possible antidotes, 11 different pharmacologic agents were tested using piglets because their skin is anatomically similar to that of man. Among the agents studied, topical implication of DMSO daily for 7 days tended to decrease the maximal diameter and accelerate healing of skin ulcers produced by intradermal doxorubicin. α-Tocopherol appeared to worsen the ulceration. None of the 11 agents studied prevented the development of ulcerations completely.

AB - Skin ulceration produced by inadvertently extravasated doxorubicin is characterized by a prolonged course accompanied by severe morbidity, and it has proven to be notoriously difficult to treat. In attempts to identify possible antidotes, 11 different pharmacologic agents were tested using piglets because their skin is anatomically similar to that of man. Among the agents studied, topical implication of DMSO daily for 7 days tended to decrease the maximal diameter and accelerate healing of skin ulcers produced by intradermal doxorubicin. α-Tocopherol appeared to worsen the ulceration. None of the 11 agents studied prevented the development of ulcerations completely.

UR - https://www.scopus.com/pages/publications/0021085750

M3 - Article

C2 - 6652625

AN - SCOPUS:0021085750

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VL - 67

SP - 1075

EP - 1078

JO - Cancer Treatment Reports

JF - Cancer Treatment Reports

IS - 12

ER -

Doxorubicin-induced skin ulcer in the piglet

Abstract

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