Down’s syndrome and the gastrointestinal tract

Peter J. Buchin, Joseph S. Levy, John N. Schullinger

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62 Scopus citations


Gastrointestinal (GI) abnormalities are frequent in patients with Down’s syndrome. In a 12-year retrospective review, we identified 187 patients with Down’s syndrome admitted to the Columbia-Presbyterian Medical Center. Twenty-seven had major GI disorders, the most common being duodenal stenosis (DS, nine), gastroesophageal reflux (GER, five), imperforate anus (five), and Hirschsprung’s disease (four). The mortality for the whole group was 11% (20 patients). The mortality in the small group of patients with duodenal stenosis was particularly high (five out of nine, or 56%). Associated congenital heart disease, especially endocardial cushion defects, and the frequent occurrence of pneumonia contributed to this high mortality rate.

Original languageEnglish
Pages (from-to)111-114
Number of pages4
JournalJournal of Clinical Gastroenterology
Issue number2
StatePublished - Apr 1986
Externally publishedYes


  • Duodenal stenosis
  • Gastroesophageal reflux


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