Down Syndrome and Thyroid Function

Evan Graber; Elizabeth Chacko; Molly O. Regelmann; Gertrude Costin; Robert Rapaport

doi:10.1016/j.ecl.2012.08.008

Down Syndrome and Thyroid Function

Evan Graber, Elizabeth Chacko, Molly O. Regelmann, Gertrude Costin, Robert Rapaport

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

Thyroid dysfunction in children with Down syndrome (DS) can occur as early as birth. As children with DS age, their risk for thyroid autoimmunity manifested as autoimmune hypothyroidism or Graves disease increases. The optimal timing and method for thyroid screening in children with DS remains controversial. The American Academy of Pediatrics recommends annual screening in this population. Consensus is needed to establish working definitions of euthyroidism and mild hypothyroidism in all infants, but especially in those with DS.

Original language	English
Pages (from-to)	735-745
Number of pages	11
Journal	Endocrinology and Metabolism Clinics of North America
Volume	41
Issue number	4
DOIs	https://doi.org/10.1016/j.ecl.2012.08.008
State	Published - Dec 2012

Keywords

Down syndrome
Euthyroidism
Hypothyroidism
Thyroid function

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10.1016/j.ecl.2012.08.008

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KW - Down syndrome

KW - Euthyroidism

KW - Hypothyroidism

KW - Thyroid function

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JF - Endocrinology and Metabolism Clinics of North America

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Down Syndrome and Thyroid Function

Abstract

Keywords

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