Down Syndrome and Thyroid Function

Evan Graber, Elizabeth Chacko, Molly O. Regelmann, Gertrude Costin, Robert Rapaport

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


Thyroid dysfunction in children with Down syndrome (DS) can occur as early as birth. As children with DS age, their risk for thyroid autoimmunity manifested as autoimmune hypothyroidism or Graves disease increases. The optimal timing and method for thyroid screening in children with DS remains controversial. The American Academy of Pediatrics recommends annual screening in this population. Consensus is needed to establish working definitions of euthyroidism and mild hypothyroidism in all infants, but especially in those with DS.

Original languageEnglish
Pages (from-to)735-745
Number of pages11
JournalEndocrinology and Metabolism Clinics of North America
Issue number4
StatePublished - Dec 2012


  • Down syndrome
  • Euthyroidism
  • Hypothyroidism
  • Thyroid function


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