Double-segment defining role of even-skipped homologs along the evolution of insect pattern formation

Xin Xu, Pin Xian Xu, Kazuhito Amanai, Yoshiaki Suzuki

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Recent studies on insect patterning suggest that the genetic hierarchy may be roughly conserved in phylogenetically divergent species but pair-rule genes may not function identically in all insects. In order to understand potential evolutionary changes in the role of the pair-rule genes, a Bombyx even-skipped homolog was cloned and its expression pattern during early embryogenesis studied. Eight stripes of Bombyx even-skipped were progressively expressed in an antero-posterior order. Later, these stripes disappeared anteriorly. Under this detection system, Bombyx even-skipped stripes clearly do not resolve into the corresponding secondary strides, an obvious difference from Drosophila and Tribolium. These results suggest that Bombyx even-skipped may serve a double-segment defining role and may determine the odd-numbered engrailed stripes.

Original languageEnglish
Pages (from-to)515-522
Number of pages8
JournalDevelopment Growth and Differentiation
Issue number4
StatePublished - 1997
Externally publishedYes


  • Even-skipped gene
  • Gap genes
  • In situ hybridization
  • Molecular evolution
  • Pair-rule genes
  • Segmentation


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