Dose antiplatelet agents; The relationship among side effects, and antithrombotic effectiveness

J. Hirsh, V. Fuster, E. Salzman

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

It is recommended that if aspirin is used as an antithrombotic agent, it should be administered in a dose of 325 mg daily. The exception is in patients with ischemic cerebrovascular disease in whom the lowest dose evaluated has been approximately 1 g/day. It is recommended that enteric coated aspirin should be used in patients who develop GI side effects with aspirin. This Grade C recommendation is based on clinical impression only. It is recommended that a lower dose of aspirin should be used in patients with ischemic cerebrovascular disease who cannot tolerate 1 g/day. It would be resonable to give these patients 325 mg/day of enteric coated aspirin if they cannot tolerate larger doses. At present there are no convincing data that indicate that the addition of dipyridamole to aspirin improves its antithrombotic efficacy. It is recommended that dipyridamole in a dose of 225 mg/day should be added to warfarin in patients with prosthetic heart valves who have developed thromboembolic complications while receiving therapeutic doses of warfarin.

Original languageEnglish
Pages (from-to)4S-10S
JournalChest
Volume89
Issue number2 SUPPL.
DOIs
StatePublished - 1986
Externally publishedYes

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