Dorso- and ventro-lateral prefrontal volume and spatial working memory in schizotypal personality disorder

Kim E. Goldstein, Erin A. Hazlett, Kimberley R. Savage, Heather A. Berlin, Holly K. Hamilton, Yuliya Zelmanova, Amy E. Look, Harold W. Koenigsberg, Effie M. Mitsis, Cheuk Y. Tang, Margaret McNamara, Larry J. Siever, Barry H. Cohen, Antonia S. New

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Schizotypal personality disorder (SPD) individuals and borderline personality disorder (BPD) individuals have been reported to show neuropsychological impairments and abnormalities in brain structure. However, relationships between neuropsychological function and brain structure in these groups are not well understood. This study compared visual-spatial working memory (SWM) and its associations with dorsolateral prefrontal cortex (DLPFC) and ventrolateral prefrontal cortex (VLPFC) gray matter volume in 18 unmedicated SPD patients with no BPD traits, 18 unmedicated BPD patients with no SPD traits, and 16 healthy controls (HC). Results showed impaired SWM in SPD but not BPD, compared with HC. Moreover, among the HC group, but not SPD patients, better SWM performance was associated with larger VLPFC (BA44/45) gray matter volume (Fisher's Z p-values <0.05). Findings suggest spatial working memory impairments may be a core neuropsychological deficit specific to SPD patients and highlight the role of VLPFC subcomponents in normal and dysfunctional memory performance.

Original languageEnglish
Pages (from-to)335-340
Number of pages6
JournalBehavioural Brain Research
Issue number2
StatePublished - 15 Apr 2011


  • Borderline personality disorder
  • Dorsolateral prefrontal cortex
  • MRI
  • Schizotypal personality disorder
  • Ventrolateral prefrontal cortex
  • Working memory


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