Dorso- and ventro-lateral prefrontal volume and spatial working memory in schizotypal personality disorder

Kim E. Goldstein; Erin A. Hazlett; Kimberley R. Savage; Heather A. Berlin; Holly K. Hamilton; Yuliya Zelmanova; Amy E. Look; Harold W. Koenigsberg; Effie M. Mitsis; Cheuk Y. Tang; Margaret McNamara; Larry J. Siever; Barry H. Cohen; Antonia S. New

doi:10.1016/j.bbr.2010.11.042

Dorso- and ventro-lateral prefrontal volume and spatial working memory in schizotypal personality disorder

Kim E. Goldstein, Erin A. Hazlett, Kimberley R. Savage, Heather A. Berlin, Holly K. Hamilton, Yuliya Zelmanova, Amy E. Look, Harold W. Koenigsberg, Effie M. Mitsis, Cheuk Y. Tang, Margaret McNamara, Larry J. Siever, Barry H. Cohen, Antonia S. New

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22 Scopus citations

Abstract

Schizotypal personality disorder (SPD) individuals and borderline personality disorder (BPD) individuals have been reported to show neuropsychological impairments and abnormalities in brain structure. However, relationships between neuropsychological function and brain structure in these groups are not well understood. This study compared visual-spatial working memory (SWM) and its associations with dorsolateral prefrontal cortex (DLPFC) and ventrolateral prefrontal cortex (VLPFC) gray matter volume in 18 unmedicated SPD patients with no BPD traits, 18 unmedicated BPD patients with no SPD traits, and 16 healthy controls (HC). Results showed impaired SWM in SPD but not BPD, compared with HC. Moreover, among the HC group, but not SPD patients, better SWM performance was associated with larger VLPFC (BA44/45) gray matter volume (Fisher's Z p-values <0.05). Findings suggest spatial working memory impairments may be a core neuropsychological deficit specific to SPD patients and highlight the role of VLPFC subcomponents in normal and dysfunctional memory performance.

Original language	English
Pages (from-to)	335-340
Number of pages	6
Journal	Behavioural Brain Research
Volume	218
Issue number	2
DOIs	https://doi.org/10.1016/j.bbr.2010.11.042
State	Published - 15 Apr 2011

Keywords

Borderline personality disorder
Dorsolateral prefrontal cortex
MRI
Schizotypal personality disorder
Ventrolateral prefrontal cortex
Working memory

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Goldstein, K. E., Hazlett, E. A., Savage, K. R., Berlin, H. A., Hamilton, H. K., Zelmanova, Y., Look, A. E., Koenigsberg, H. W., Mitsis, E. M., Tang, C. Y., McNamara, M., Siever, L. J., Cohen, B. H., & New, A. S. (2011). Dorso- and ventro-lateral prefrontal volume and spatial working memory in schizotypal personality disorder. Behavioural Brain Research, 218(2), 335-340. https://doi.org/10.1016/j.bbr.2010.11.042

@article{5807231d53a440019b4714f8fd46444d,

title = "Dorso- and ventro-lateral prefrontal volume and spatial working memory in schizotypal personality disorder",

abstract = "Schizotypal personality disorder (SPD) individuals and borderline personality disorder (BPD) individuals have been reported to show neuropsychological impairments and abnormalities in brain structure. However, relationships between neuropsychological function and brain structure in these groups are not well understood. This study compared visual-spatial working memory (SWM) and its associations with dorsolateral prefrontal cortex (DLPFC) and ventrolateral prefrontal cortex (VLPFC) gray matter volume in 18 unmedicated SPD patients with no BPD traits, 18 unmedicated BPD patients with no SPD traits, and 16 healthy controls (HC). Results showed impaired SWM in SPD but not BPD, compared with HC. Moreover, among the HC group, but not SPD patients, better SWM performance was associated with larger VLPFC (BA44/45) gray matter volume (Fisher's Z p-values <0.05). Findings suggest spatial working memory impairments may be a core neuropsychological deficit specific to SPD patients and highlight the role of VLPFC subcomponents in normal and dysfunctional memory performance.",

keywords = "Borderline personality disorder, Dorsolateral prefrontal cortex, MRI, Schizotypal personality disorder, Ventrolateral prefrontal cortex, Working memory",

author = "Goldstein, {Kim E.} and Hazlett, {Erin A.} and Savage, {Kimberley R.} and Berlin, {Heather A.} and Hamilton, {Holly K.} and Yuliya Zelmanova and Look, {Amy E.} and Koenigsberg, {Harold W.} and Mitsis, {Effie M.} and Tang, {Cheuk Y.} and Margaret McNamara and Siever, {Larry J.} and Cohen, {Barry H.} and New, {Antonia S.}",

note = "Funding Information: This work was supported by NIMH grant R01MH073911 to Dr. Hazlett. Other support came from Grant Number MO1-RR00071 from the National Center for Research Resources (NCRR) , a component of the National Institutes of Health (NIH) and the Mental Illness Research, Education and Clinical Center, VISN 3 Veterans Health Administration. We thank Dr. Monte Buchsbaum who kindly allowed the use of in-house MIPS software. ",

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doi = "10.1016/j.bbr.2010.11.042",

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Goldstein, KE , Hazlett, EA, Savage, KR, Berlin, HA, Hamilton, HK, Zelmanova, Y, Look, AE, Koenigsberg, HW, Mitsis, EM, Tang, CY, McNamara, M, Siever, LJ, Cohen, BH & New, AS 2011, 'Dorso- and ventro-lateral prefrontal volume and spatial working memory in schizotypal personality disorder', Behavioural Brain Research, vol. 218, no. 2, pp. 335-340. https://doi.org/10.1016/j.bbr.2010.11.042

TY - JOUR

T1 - Dorso- and ventro-lateral prefrontal volume and spatial working memory in schizotypal personality disorder

AU - Goldstein, Kim E.

AU - Hazlett, Erin A.

AU - Savage, Kimberley R.

AU - Berlin, Heather A.

AU - Hamilton, Holly K.

AU - Zelmanova, Yuliya

AU - Look, Amy E.

AU - Koenigsberg, Harold W.

AU - Mitsis, Effie M.

AU - Tang, Cheuk Y.

AU - McNamara, Margaret

AU - Siever, Larry J.

AU - Cohen, Barry H.

AU - New, Antonia S.

N1 - Funding Information: This work was supported by NIMH grant R01MH073911 to Dr. Hazlett. Other support came from Grant Number MO1-RR00071 from the National Center for Research Resources (NCRR) , a component of the National Institutes of Health (NIH) and the Mental Illness Research, Education and Clinical Center, VISN 3 Veterans Health Administration. We thank Dr. Monte Buchsbaum who kindly allowed the use of in-house MIPS software.

PY - 2011/4/15

Y1 - 2011/4/15

N2 - Schizotypal personality disorder (SPD) individuals and borderline personality disorder (BPD) individuals have been reported to show neuropsychological impairments and abnormalities in brain structure. However, relationships between neuropsychological function and brain structure in these groups are not well understood. This study compared visual-spatial working memory (SWM) and its associations with dorsolateral prefrontal cortex (DLPFC) and ventrolateral prefrontal cortex (VLPFC) gray matter volume in 18 unmedicated SPD patients with no BPD traits, 18 unmedicated BPD patients with no SPD traits, and 16 healthy controls (HC). Results showed impaired SWM in SPD but not BPD, compared with HC. Moreover, among the HC group, but not SPD patients, better SWM performance was associated with larger VLPFC (BA44/45) gray matter volume (Fisher's Z p-values <0.05). Findings suggest spatial working memory impairments may be a core neuropsychological deficit specific to SPD patients and highlight the role of VLPFC subcomponents in normal and dysfunctional memory performance.

AB - Schizotypal personality disorder (SPD) individuals and borderline personality disorder (BPD) individuals have been reported to show neuropsychological impairments and abnormalities in brain structure. However, relationships between neuropsychological function and brain structure in these groups are not well understood. This study compared visual-spatial working memory (SWM) and its associations with dorsolateral prefrontal cortex (DLPFC) and ventrolateral prefrontal cortex (VLPFC) gray matter volume in 18 unmedicated SPD patients with no BPD traits, 18 unmedicated BPD patients with no SPD traits, and 16 healthy controls (HC). Results showed impaired SWM in SPD but not BPD, compared with HC. Moreover, among the HC group, but not SPD patients, better SWM performance was associated with larger VLPFC (BA44/45) gray matter volume (Fisher's Z p-values <0.05). Findings suggest spatial working memory impairments may be a core neuropsychological deficit specific to SPD patients and highlight the role of VLPFC subcomponents in normal and dysfunctional memory performance.

KW - Borderline personality disorder

KW - Dorsolateral prefrontal cortex

KW - MRI

KW - Schizotypal personality disorder

KW - Ventrolateral prefrontal cortex

KW - Working memory

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U2 - 10.1016/j.bbr.2010.11.042

DO - 10.1016/j.bbr.2010.11.042

M3 - Article

C2 - 21115066

AN - SCOPUS:79151477345

SN - 0166-4328

VL - 218

SP - 335

EP - 340

JO - Behavioural Brain Research

JF - Behavioural Brain Research

IS - 2

ER -

Dorso- and ventro-lateral prefrontal volume and spatial working memory in schizotypal personality disorder

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Keywords

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