Doppelgänger dilemma: Leiomyoma versus uveal melanoma

Ankit Singh Tomar, Anthony Fam, Paul T. Finger, Codrin E. Iacob

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: Ciliary body tumors can remain undetected and achieve large dimensions. Pigmented ciliary body tumors include: melanoma, leiomyoma and melanocytoma, however correct diagnosis may require tissue diagnosis with immunohistochemical stains. Case presentation: Two men presented with identical ciliochoroidal tumors. Both had darkly pigmented dome-shaped anterior uveal masses, exudative retinal detachments and transillumination shadowing. Ocular PET-CT imaging revealed that both were metabolically active consistent with a diagnosis of cancer. However, immunohistochemical examination revealed one a leiomyoma and the other melanoma. Conclusion: Uveal leiomyoma can be an indistinguishable doppelgänger to ciliochoroidal melanoma, where the diagnosis can only be established by immunohistopathology.

Original languageEnglish
Article number101040
JournalAmerican Journal of Ophthalmology Case Reports
StatePublished - Jun 2021
Externally publishedYes


  • Benign
  • Immunohistochemistry
  • Leiomyoma
  • Melanoma
  • Uvea


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