Doppelgänger dilemma: Leiomyoma versus uveal melanoma

Ankit Singh Tomar; Anthony Fam; Paul T. Finger; Codrin E. Iacob

doi:10.1016/j.ajoc.2021.101040

Doppelgänger dilemma: Leiomyoma versus uveal melanoma

Ankit Singh Tomar, Anthony Fam, Paul T. Finger, Codrin E. Iacob

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background: Ciliary body tumors can remain undetected and achieve large dimensions. Pigmented ciliary body tumors include: melanoma, leiomyoma and melanocytoma, however correct diagnosis may require tissue diagnosis with immunohistochemical stains. Case presentation: Two men presented with identical ciliochoroidal tumors. Both had darkly pigmented dome-shaped anterior uveal masses, exudative retinal detachments and transillumination shadowing. Ocular PET-CT imaging revealed that both were metabolically active consistent with a diagnosis of cancer. However, immunohistochemical examination revealed one a leiomyoma and the other melanoma. Conclusion: Uveal leiomyoma can be an indistinguishable doppelgänger to ciliochoroidal melanoma, where the diagnosis can only be established by immunohistopathology.

Original language	English
Article number	101040
Journal	American Journal of Ophthalmology Case Reports
Volume	22
DOIs	https://doi.org/10.1016/j.ajoc.2021.101040
State	Published - Jun 2021
Externally published	Yes

Keywords

Benign
Immunohistochemistry
Leiomyoma
Melanoma
Uvea

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10.1016/j.ajoc.2021.101040

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title = "Doppelg{\"a}nger dilemma: Leiomyoma versus uveal melanoma",

abstract = "Background: Ciliary body tumors can remain undetected and achieve large dimensions. Pigmented ciliary body tumors include: melanoma, leiomyoma and melanocytoma, however correct diagnosis may require tissue diagnosis with immunohistochemical stains. Case presentation: Two men presented with identical ciliochoroidal tumors. Both had darkly pigmented dome-shaped anterior uveal masses, exudative retinal detachments and transillumination shadowing. Ocular PET-CT imaging revealed that both were metabolically active consistent with a diagnosis of cancer. However, immunohistochemical examination revealed one a leiomyoma and the other melanoma. Conclusion: Uveal leiomyoma can be an indistinguishable doppelg{\"a}nger to ciliochoroidal melanoma, where the diagnosis can only be established by immunohistopathology.",

keywords = "Benign, Immunohistochemistry, Leiomyoma, Melanoma, Uvea",

author = "Tomar, {Ankit Singh} and Anthony Fam and Finger, {Paul T.} and Iacob, {Codrin E.}",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2021",

month = jun,

doi = "10.1016/j.ajoc.2021.101040",

language = "English",

volume = "22",

journal = "American Journal of Ophthalmology Case Reports",

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TY - JOUR

T1 - Doppelgänger dilemma

T2 - Leiomyoma versus uveal melanoma

AU - Tomar, Ankit Singh

AU - Fam, Anthony

AU - Finger, Paul T.

AU - Iacob, Codrin E.

PY - 2021/6

Y1 - 2021/6

N2 - Background: Ciliary body tumors can remain undetected and achieve large dimensions. Pigmented ciliary body tumors include: melanoma, leiomyoma and melanocytoma, however correct diagnosis may require tissue diagnosis with immunohistochemical stains. Case presentation: Two men presented with identical ciliochoroidal tumors. Both had darkly pigmented dome-shaped anterior uveal masses, exudative retinal detachments and transillumination shadowing. Ocular PET-CT imaging revealed that both were metabolically active consistent with a diagnosis of cancer. However, immunohistochemical examination revealed one a leiomyoma and the other melanoma. Conclusion: Uveal leiomyoma can be an indistinguishable doppelgänger to ciliochoroidal melanoma, where the diagnosis can only be established by immunohistopathology.

AB - Background: Ciliary body tumors can remain undetected and achieve large dimensions. Pigmented ciliary body tumors include: melanoma, leiomyoma and melanocytoma, however correct diagnosis may require tissue diagnosis with immunohistochemical stains. Case presentation: Two men presented with identical ciliochoroidal tumors. Both had darkly pigmented dome-shaped anterior uveal masses, exudative retinal detachments and transillumination shadowing. Ocular PET-CT imaging revealed that both were metabolically active consistent with a diagnosis of cancer. However, immunohistochemical examination revealed one a leiomyoma and the other melanoma. Conclusion: Uveal leiomyoma can be an indistinguishable doppelgänger to ciliochoroidal melanoma, where the diagnosis can only be established by immunohistopathology.

KW - Benign

KW - Immunohistochemistry

KW - Leiomyoma

KW - Melanoma

KW - Uvea

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DO - 10.1016/j.ajoc.2021.101040

M3 - Article

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JO - American Journal of Ophthalmology Case Reports

JF - American Journal of Ophthalmology Case Reports

M1 - 101040

ER -

Doppelgänger dilemma: Leiomyoma versus uveal melanoma

Abstract

Keywords

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