Dopaminergic contributions to modulatory functions of a dual-transmitter interneuron in Aplysia

Michael R. Due, Jian Jing, Klaudiusz R. Weiss

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The feeding central pattern generator of Aplysia produces motor programs that can differ in the degree to which they are ingestive or egestive. A number of pattern-generating interneurons that play an important role in shaping motor programs have been identified. One of these interneurons, B65, is unusual in that it contains two classical neurotransmitters, dopamine and γ-aminobutyric acid. Here, we study the role of one of these transmitters, dopamine, using a combination of pharmacological and electrophysiological means. We show that B65 uses dopamine to elicit fast synaptic potentials in several follower neurons. Furthermore, we demonstrate that the dopamine antagonist sulpiride mimics the effect of bilateral B65 hyperpolarization on egestive motor programs. Thus our data suggest that dopaminergic transmission serves to increase the degree of egestiveness of motor programs, and decrease the duration of the protraction phase.

Original languageEnglish
Pages (from-to)53-57
Number of pages5
JournalNeuroscience Letters
Volume358
Issue number1
DOIs
StatePublished - 18 Mar 2004

Keywords

  • Aplysia
  • Central Pattern Generator
  • Dopamine
  • Feeding
  • Modulation
  • Motor program

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