Dopamine transporter gene, response to methylphenidate and cerebral blood flow in attention-deficit/hyperactivity disorder: A pilot study

Luis A. Rohde; Tatiana Roman; Claudia Szobot; Renato D. Cunha; Mara H. Hutz; Joseph Biederman

doi:10.1002/syn.10186

Dopamine transporter gene, response to methylphenidate and cerebral blood flow in attention-deficit/hyperactivity disorder: A pilot study

Luis A. Rohde, Tatiana Roman, Claudia Szobot, Renato D. Cunha, Mara H. Hutz, Joseph Biederman

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

The homozygosity of the 10-repeat allele at dopamine transporter gene (DAT1) seems to be associated with a poor response to methylphenidate (MPH) in children with attention-deficit/hyperactivity disorder (ADHD). This pilot study aimed to simultaneously assess polymorphisms at DAT1, response to MPH, and neuroimaging. Only ADHD children with at least a moderate response to MPH were included. Significantly higher regional cerebral blood flows assessed by single photon emission computerized tomography (SPECT) were detected in medial frontal and left basal ganglia areas in children with homozygosity for the 10-repeat allele at DAT1 gene (n = 4) than in children without this genotype (n = 4) (P < 0.05). These findings provide a preliminary connection between pharmacogenetics and neurobiological investigations on stimulant treatment of ADHD.

Original language	English
Pages (from-to)	87-89
Number of pages	3
Journal	Synapse
Volume	48
Issue number	2
DOIs	https://doi.org/10.1002/syn.10186
State	Published - 1 May 2003
Externally published	Yes

Keywords

ADHD
DAT1 gene
Methylphenidate
SPECT

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10.1002/syn.10186

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abstract = "The homozygosity of the 10-repeat allele at dopamine transporter gene (DAT1) seems to be associated with a poor response to methylphenidate (MPH) in children with attention-deficit/hyperactivity disorder (ADHD). This pilot study aimed to simultaneously assess polymorphisms at DAT1, response to MPH, and neuroimaging. Only ADHD children with at least a moderate response to MPH were included. Significantly higher regional cerebral blood flows assessed by single photon emission computerized tomography (SPECT) were detected in medial frontal and left basal ganglia areas in children with homozygosity for the 10-repeat allele at DAT1 gene (n = 4) than in children without this genotype (n = 4) (P < 0.05). These findings provide a preliminary connection between pharmacogenetics and neurobiological investigations on stimulant treatment of ADHD.",

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AU - Roman, Tatiana

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AU - Cunha, Renato D.

AU - Hutz, Mara H.

AU - Biederman, Joseph

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KW - Methylphenidate

KW - SPECT

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Dopamine transporter gene, response to methylphenidate and cerebral blood flow in attention-deficit/hyperactivity disorder: A pilot study

Abstract

Keywords

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