Dopamine-β-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy

Daniel P. Van Kammen; Lee S. Mann; David E. Sternberg; Mika Scheinin; Philip T. Ninan; Stephen R. Marder; Welmoet B. Van Kammen; Ronald O. Rieder; Markku Linnoila

doi:10.1126/science.6133351

Dopamine-β-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy

Daniel P. Van Kammen, Lee S. Mann, David E. Sternberg, Mika Scheinin, Philip T. Ninan, Stephen R. Marder, Welmoet B. Van Kammen, Ronald O. Rieder, Markku Linnoila

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

Schizophrenic patients with high ventricle brain ratios and cortical brain atrophy, as shown by computerized tomography, had decreased spinal fluid concentrations of homovanillic acid and dopamine-β-hydroxylase activity. These decreased cerebral spinal fluid concentrations in patients with brain atrophy support the proposal of disturbed noradrenaline and dopamine neurotransmission in a subgroup of schizophrenic patients.

Original language	English
Pages (from-to)	974-977
Number of pages	4
Journal	Science
Volume	220
Issue number	4600
DOIs	https://doi.org/10.1126/science.6133351
State	Published - 1983
Externally published	Yes

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title = "Dopamine-β-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy",

abstract = "Schizophrenic patients with high ventricle brain ratios and cortical brain atrophy, as shown by computerized tomography, had decreased spinal fluid concentrations of homovanillic acid and dopamine-β-hydroxylase activity. These decreased cerebral spinal fluid concentrations in patients with brain atrophy support the proposal of disturbed noradrenaline and dopamine neurotransmission in a subgroup of schizophrenic patients.",

author = "{Van Kammen}, {Daniel P.} and Mann, {Lee S.} and Sternberg, {David E.} and Mika Scheinin and Ninan, {Philip T.} and Marder, {Stephen R.} and {Van Kammen}, {Welmoet B.} and Rieder, {Ronald O.} and Markku Linnoila",

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doi = "10.1126/science.6133351",

language = "English",

volume = "220",

pages = "974--977",

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T1 - Dopamine-β-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy

AU - Van Kammen, Daniel P.

AU - Mann, Lee S.

AU - Sternberg, David E.

AU - Scheinin, Mika

AU - Ninan, Philip T.

AU - Marder, Stephen R.

AU - Van Kammen, Welmoet B.

AU - Rieder, Ronald O.

AU - Linnoila, Markku

PY - 1983

Y1 - 1983

N2 - Schizophrenic patients with high ventricle brain ratios and cortical brain atrophy, as shown by computerized tomography, had decreased spinal fluid concentrations of homovanillic acid and dopamine-β-hydroxylase activity. These decreased cerebral spinal fluid concentrations in patients with brain atrophy support the proposal of disturbed noradrenaline and dopamine neurotransmission in a subgroup of schizophrenic patients.

AB - Schizophrenic patients with high ventricle brain ratios and cortical brain atrophy, as shown by computerized tomography, had decreased spinal fluid concentrations of homovanillic acid and dopamine-β-hydroxylase activity. These decreased cerebral spinal fluid concentrations in patients with brain atrophy support the proposal of disturbed noradrenaline and dopamine neurotransmission in a subgroup of schizophrenic patients.

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U2 - 10.1126/science.6133351

DO - 10.1126/science.6133351

M3 - Article

C2 - 6133351

AN - SCOPUS:0020534514

SN - 0036-8075

VL - 220

SP - 974

EP - 977

JO - Science

JF - Science

IS - 4600

ER -

Dopamine-β-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy

Abstract

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