Donepezil in the treatment of ADHD-like symptoms in youths with pervasive developmental disorder: A case series

Robert L. Doyle; Jean Frazier; Thomas J. Spencer; Daniel Geller; Joseph Biederman; Timothy Wilens

doi:10.1177/1087054705284091

Donepezil in the treatment of ADHD-like symptoms in youths with pervasive developmental disorder: A case series

Robert L. Doyle, Jean Frazier, Thomas J. Spencer, Daniel Geller, Joseph Biederman, Timothy Wilens

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Background: Recent studies reported ADHD-like symptoms and cognitive deficits in pervasive developmental disorder (PDD). Because work in dementia documents improvement in executive function deficits with the acetylcholinesterase inhibitor donepezil, the authors reason that similar benefits could be obtained in PDD. Method: The authors describe eight cases of PDD youth ages 10 to 17 treated with donepezil targeting ADHD-like symptoms associated with PDD. Results: Most participants improve ADHD-like symptomatology. In addition, improvement in communication and socialization is noted. Conclusion: Donepezil may have a role in treating ADHD-like symptoms in children with PDD.

Original language	English
Pages (from-to)	543-549
Number of pages	7
Journal	Journal of Attention Disorders
Volume	9
Issue number	3
DOIs	https://doi.org/10.1177/1087054705284091
State	Published - Feb 2006
Externally published	Yes

Keywords

Donepezil
PDD
Pediatric

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10.1177/1087054705284091

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title = "Donepezil in the treatment of ADHD-like symptoms in youths with pervasive developmental disorder: A case series",

abstract = "Background: Recent studies reported ADHD-like symptoms and cognitive deficits in pervasive developmental disorder (PDD). Because work in dementia documents improvement in executive function deficits with the acetylcholinesterase inhibitor donepezil, the authors reason that similar benefits could be obtained in PDD. Method: The authors describe eight cases of PDD youth ages 10 to 17 treated with donepezil targeting ADHD-like symptoms associated with PDD. Results: Most participants improve ADHD-like symptomatology. In addition, improvement in communication and socialization is noted. Conclusion: Donepezil may have a role in treating ADHD-like symptoms in children with PDD.",

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author = "Doyle, {Robert L.} and Jean Frazier and Spencer, {Thomas J.} and Daniel Geller and Joseph Biederman and Timothy Wilens",

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T1 - Donepezil in the treatment of ADHD-like symptoms in youths with pervasive developmental disorder

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AU - Doyle, Robert L.

AU - Frazier, Jean

AU - Spencer, Thomas J.

AU - Geller, Daniel

AU - Biederman, Joseph

AU - Wilens, Timothy

PY - 2006/2

Y1 - 2006/2

N2 - Background: Recent studies reported ADHD-like symptoms and cognitive deficits in pervasive developmental disorder (PDD). Because work in dementia documents improvement in executive function deficits with the acetylcholinesterase inhibitor donepezil, the authors reason that similar benefits could be obtained in PDD. Method: The authors describe eight cases of PDD youth ages 10 to 17 treated with donepezil targeting ADHD-like symptoms associated with PDD. Results: Most participants improve ADHD-like symptomatology. In addition, improvement in communication and socialization is noted. Conclusion: Donepezil may have a role in treating ADHD-like symptoms in children with PDD.

AB - Background: Recent studies reported ADHD-like symptoms and cognitive deficits in pervasive developmental disorder (PDD). Because work in dementia documents improvement in executive function deficits with the acetylcholinesterase inhibitor donepezil, the authors reason that similar benefits could be obtained in PDD. Method: The authors describe eight cases of PDD youth ages 10 to 17 treated with donepezil targeting ADHD-like symptoms associated with PDD. Results: Most participants improve ADHD-like symptomatology. In addition, improvement in communication and socialization is noted. Conclusion: Donepezil may have a role in treating ADHD-like symptoms in children with PDD.

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Donepezil in the treatment of ADHD-like symptoms in youths with pervasive developmental disorder: A case series

Abstract

Keywords

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