Dogs are highly susceptible to H5N1 avian influenza virus

Ying Chen; Gongxun Zhong; Guojun Wang; Guohua Deng; Yanbing Li; Jianzhong Shi; Zhuo Zhang; Yuntao Guan; Yongping Jiang; Zhigao Bu; Yoshihiro Kawaoka; Hualan Chen

doi:10.1016/j.virol.2010.05.024

Dogs are highly susceptible to H5N1 avian influenza virus

Ying Chen
, Gongxun Zhong
, Guojun Wang
, Guohua Deng
, Yanbing Li
, Jianzhong Shi
, Zhuo Zhang
, Yuntao Guan
, Yongping Jiang
, Zhigao Bu
, Yoshihiro Kawaoka
, Hualan Chen

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Replication of avian influenza viruses (AIVs) in dogs may facilitate their adaptation in humans; however, the data to date on H5N1 influenza virus infection in dogs are conflicting. To elucidate the susceptibility of dogs to this pathogen, we infected two groups of 6 beagles with 10⁶ 50% egg-infectious dose of H5N1 AIV A/bar-headed goose/Qinghai/3/05 (BHG/QH/3/05) intranasally (i.n.) and intratracheally (i.t.), respectively. The dogs showed disease symptoms, including anorexia, fever, conjunctivitis, labored breathing and cough, and one i.t. inoculated animal died on day 4 post-infection. Virus shedding was detected from all 6 animals inoculated i.n. and one inoculated i.t. Virus replication was detected in all animals that were euthanized on day 3 or day 5 post-infection and in the animal that died on day 4 post-infection. Our results demonstrate that dogs are highly susceptible to H5N1 AIV and may serve as an intermediate host to transfer this virus to humans.

Original language	English
Pages (from-to)	15-19
Number of pages	5
Journal	Virology
Volume	405
Issue number	1
DOIs	https://doi.org/10.1016/j.virol.2010.05.024
State	Published - Sep 2010
Externally published	Yes

Keywords

Dogs
H5N1 influenza virus
Replication

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10.1016/j.virol.2010.05.024

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@article{0da03806f095474db981c4042986ff31,

title = "Dogs are highly susceptible to H5N1 avian influenza virus",

abstract = "Replication of avian influenza viruses (AIVs) in dogs may facilitate their adaptation in humans; however, the data to date on H5N1 influenza virus infection in dogs are conflicting. To elucidate the susceptibility of dogs to this pathogen, we infected two groups of 6 beagles with 106 50\% egg-infectious dose of H5N1 AIV A/bar-headed goose/Qinghai/3/05 (BHG/QH/3/05) intranasally (i.n.) and intratracheally (i.t.), respectively. The dogs showed disease symptoms, including anorexia, fever, conjunctivitis, labored breathing and cough, and one i.t. inoculated animal died on day 4 post-infection. Virus shedding was detected from all 6 animals inoculated i.n. and one inoculated i.t. Virus replication was detected in all animals that were euthanized on day 3 or day 5 post-infection and in the animal that died on day 4 post-infection. Our results demonstrate that dogs are highly susceptible to H5N1 AIV and may serve as an intermediate host to transfer this virus to humans.",

keywords = "Dogs, H5N1 influenza virus, Replication",

author = "Ying Chen and Gongxun Zhong and Guojun Wang and Guohua Deng and Yanbing Li and Jianzhong Shi and Zhuo Zhang and Yuntao Guan and Yongping Jiang and Zhigao Bu and Yoshihiro Kawaoka and Hualan Chen",

note = "Funding Information: We thank Susan Watson for editing the manuscript. This work was supported by Chinese National Natural Science Foundation 30825032 , by the Chinese National Key Basic Research Program (973) ( 2010CB534000 , 2005CB523005 and 2005CB523200 ), by the Chinese National S\&T Plan Grant 2006BAD06A05 and 2009ZX10004-214 , by a grant-in-aid for Specially Promoted Research, by a contract research fund for the Program of Funding Research Centers for Emerging and Reemerging Infectious Diseases from the Ministry of Education, Culture, Sports, Science and Technology of Japan, by the ERATO (Exploratory Research for Advanced Technology) grant from the Japan Science and Technology Agency and by Public Health Service research grants from the National Institute of Allergy and Infectious Diseases.",

year = "2010",

month = sep,

doi = "10.1016/j.virol.2010.05.024",

language = "English",

volume = "405",

pages = "15--19",

journal = "Virology",

issn = "0042-6822",

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T1 - Dogs are highly susceptible to H5N1 avian influenza virus

AU - Chen, Ying

AU - Zhong, Gongxun

AU - Wang, Guojun

AU - Deng, Guohua

AU - Li, Yanbing

AU - Shi, Jianzhong

AU - Zhang, Zhuo

AU - Guan, Yuntao

AU - Jiang, Yongping

AU - Bu, Zhigao

AU - Kawaoka, Yoshihiro

AU - Chen, Hualan

N1 - Funding Information: We thank Susan Watson for editing the manuscript. This work was supported by Chinese National Natural Science Foundation 30825032 , by the Chinese National Key Basic Research Program (973) ( 2010CB534000 , 2005CB523005 and 2005CB523200 ), by the Chinese National S&T Plan Grant 2006BAD06A05 and 2009ZX10004-214 , by a grant-in-aid for Specially Promoted Research, by a contract research fund for the Program of Funding Research Centers for Emerging and Reemerging Infectious Diseases from the Ministry of Education, Culture, Sports, Science and Technology of Japan, by the ERATO (Exploratory Research for Advanced Technology) grant from the Japan Science and Technology Agency and by Public Health Service research grants from the National Institute of Allergy and Infectious Diseases.

PY - 2010/9

Y1 - 2010/9

N2 - Replication of avian influenza viruses (AIVs) in dogs may facilitate their adaptation in humans; however, the data to date on H5N1 influenza virus infection in dogs are conflicting. To elucidate the susceptibility of dogs to this pathogen, we infected two groups of 6 beagles with 106 50% egg-infectious dose of H5N1 AIV A/bar-headed goose/Qinghai/3/05 (BHG/QH/3/05) intranasally (i.n.) and intratracheally (i.t.), respectively. The dogs showed disease symptoms, including anorexia, fever, conjunctivitis, labored breathing and cough, and one i.t. inoculated animal died on day 4 post-infection. Virus shedding was detected from all 6 animals inoculated i.n. and one inoculated i.t. Virus replication was detected in all animals that were euthanized on day 3 or day 5 post-infection and in the animal that died on day 4 post-infection. Our results demonstrate that dogs are highly susceptible to H5N1 AIV and may serve as an intermediate host to transfer this virus to humans.

AB - Replication of avian influenza viruses (AIVs) in dogs may facilitate their adaptation in humans; however, the data to date on H5N1 influenza virus infection in dogs are conflicting. To elucidate the susceptibility of dogs to this pathogen, we infected two groups of 6 beagles with 106 50% egg-infectious dose of H5N1 AIV A/bar-headed goose/Qinghai/3/05 (BHG/QH/3/05) intranasally (i.n.) and intratracheally (i.t.), respectively. The dogs showed disease symptoms, including anorexia, fever, conjunctivitis, labored breathing and cough, and one i.t. inoculated animal died on day 4 post-infection. Virus shedding was detected from all 6 animals inoculated i.n. and one inoculated i.t. Virus replication was detected in all animals that were euthanized on day 3 or day 5 post-infection and in the animal that died on day 4 post-infection. Our results demonstrate that dogs are highly susceptible to H5N1 AIV and may serve as an intermediate host to transfer this virus to humans.

KW - Dogs

KW - H5N1 influenza virus

KW - Replication

UR - https://www.scopus.com/pages/publications/77955509081

U2 - 10.1016/j.virol.2010.05.024

DO - 10.1016/j.virol.2010.05.024

M3 - Article

C2 - 20580396

AN - SCOPUS:77955509081

SN - 0042-6822

VL - 405

SP - 15

EP - 19

JO - Virology

JF - Virology

IS - 1

ER -

Dogs are highly susceptible to H5N1 avian influenza virus

Abstract

Keywords

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