Does radiation-induced c-MYC amplification initiate breast oncogenesis?

Mark A. Wade, Felicity E.B. May, Ken Onel, James M. Allan

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The MYC (v-myc avian myelocytomatosis viral oncogene homolog; c-MYC) locus on chromosome 8q is susceptible to high-level amplification following exposure of human breast cells to ionizing radiation, and c-MYC amplification is a common feature of both radiogenic adenocarcinoma and radiogenic angiosarcoma of the breast. Taken together, these observations suggest common breast-specific susceptibility factors that predispose cells to amplification of this critical proto-oncogene and the development of radiogenic cancer in multiple tissue types of this radiosensitive organ.

Original languageEnglish
Article numbere1010950
JournalMolecular and Cellular Oncology
Volume3
Issue number1
DOIs
StatePublished - 2 Jan 2016
Externally publishedYes

Keywords

  • MYC
  • adenocarcinoma
  • amplification
  • oncogene
  • radiosensitive

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