TY - JOUR
T1 - Does Local Cardiac Hypothermia During Cardiopulmonary Bypass Protect the Myocardium from Long-Term Morphological and Functional Injury?
AU - Schraut, Wolfgang
AU - Lamberti, John J.
AU - Kampman, Ken
AU - Anagnostopoulos, Constantine
AU - Replogle, Robert
AU - Glagov, Seymour
N1 - Funding Information:
From the Departments of Surgery and Pathology, The University of Chicago Pritzker School of Medicine, Chicago, IL. Supported by the Louis L. Block Fund of The University of Chicago, Grant HL17648 awarded by the National Heart, Lung, and Blood Institute, and Chicago Heart Association Grants A75-11 and C76-5.
PY - 1977
Y1 - 1977
N2 - Twenty-eight dogs were subjected to 90 minutes of hypothermic (30°C) cardiopulmonary bypass with moderate hemodilution. In 6 dogs the heart was vented and beating for 60 minutes. Eight dogs underwent ventricular fibrillation with coronary perfusion (VF + CP). In 14 dogs the aorta was cross-clamped for 60 minutes while the myocardium was protected by local cardiac hypothermia (ICA + LCH). Eighteeen animals survived. Hemodynamic studies at seven weeks revealed no major differences among the three groups. At postmortem examination, no gross scarring was noted in any heart. Microscopical examination of 14 hearts was completely normal. In the VF + CP group, 2 hearts had isolated microscopical scars. Similar linear subendocardial scars (<1.5 × 0.5 mm) were noted in 2 hearts subjected to ICA + LCH. Survival after 60 minutes of VF + CP or ICA + LCH did not result in long-term morphological injury to or functional impairment of the myocardium.
AB - Twenty-eight dogs were subjected to 90 minutes of hypothermic (30°C) cardiopulmonary bypass with moderate hemodilution. In 6 dogs the heart was vented and beating for 60 minutes. Eight dogs underwent ventricular fibrillation with coronary perfusion (VF + CP). In 14 dogs the aorta was cross-clamped for 60 minutes while the myocardium was protected by local cardiac hypothermia (ICA + LCH). Eighteeen animals survived. Hemodynamic studies at seven weeks revealed no major differences among the three groups. At postmortem examination, no gross scarring was noted in any heart. Microscopical examination of 14 hearts was completely normal. In the VF + CP group, 2 hearts had isolated microscopical scars. Similar linear subendocardial scars (<1.5 × 0.5 mm) were noted in 2 hearts subjected to ICA + LCH. Survival after 60 minutes of VF + CP or ICA + LCH did not result in long-term morphological injury to or functional impairment of the myocardium.
UR - http://www.scopus.com/inward/record.url?scp=0017661406&partnerID=8YFLogxK
U2 - 10.1016/S0003-4975(10)63406-6
DO - 10.1016/S0003-4975(10)63406-6
M3 - Article
AN - SCOPUS:0017661406
SN - 0003-4975
VL - 24
SP - 315
EP - 322
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 4
ER -