Does Local Cardiac Hypothermia During Cardiopulmonary Bypass Protect the Myocardium from Long-Term Morphological and Functional Injury?

Wolfgang Schraut, John J. Lamberti, Ken Kampman, Constantine Anagnostopoulos, Robert Replogle, Seymour Glagov

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Twenty-eight dogs were subjected to 90 minutes of hypothermic (30°C) cardiopulmonary bypass with moderate hemodilution. In 6 dogs the heart was vented and beating for 60 minutes. Eight dogs underwent ventricular fibrillation with coronary perfusion (VF + CP). In 14 dogs the aorta was cross-clamped for 60 minutes while the myocardium was protected by local cardiac hypothermia (ICA + LCH). Eighteeen animals survived. Hemodynamic studies at seven weeks revealed no major differences among the three groups. At postmortem examination, no gross scarring was noted in any heart. Microscopical examination of 14 hearts was completely normal. In the VF + CP group, 2 hearts had isolated microscopical scars. Similar linear subendocardial scars (<1.5 × 0.5 mm) were noted in 2 hearts subjected to ICA + LCH. Survival after 60 minutes of VF + CP or ICA + LCH did not result in long-term morphological injury to or functional impairment of the myocardium.

Original languageEnglish
Pages (from-to)315-322
Number of pages8
JournalAnnals of Thoracic Surgery
Volume24
Issue number4
DOIs
StatePublished - 1977
Externally publishedYes

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