Does Caffeine Consumption Increase the Risk of New-Onset Atrial Fibrillation?

Ramy Abdelfattah, Haroon Kamran, Jason Lazar, John Kassotis

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Objective: Caffeine has been considered a trigger for atrial fibrillation (AF). We conducted a meta-analysis including a dose-response analysis to assess the relationship between caffeine consumed and incidence of AF. Methods: Data from selected studies represented 176,675 subjects (AF in 9,987 [5.7%]). Caffeine content varied widely, ranging from 40 to 180 mg per cup of coffee. For purposes of the calculations in this study, we assumed 140 mg of caffeine in a standard 12-oz cup of coffee. Results: No significant difference was found in AF incidence when the subjects consuming less than 2 cups of coffee per day were compared to subjects with higher consumption, 1.068 (0.937-1.216). The risk of AF was higher among subjects consuming less than 2 cups of coffee daily when compared to higher daily consumption subjects. A lower incidence of AF was found among people consuming more than 436 mg daily. Conclusion: The incidence of AF is not increased by coffee consumption. In fact, we found a lower incidence of AF when caffeine consumption exceeded 436 mg/day. Therefore, based on available evidence there is no association between caffeine intake and AF risk.

Original languageEnglish
Pages (from-to)106-114
Number of pages9
Issue number2
StatePublished - 1 Jul 2018
Externally publishedYes


  • Arrhythmia
  • Atrial fibrillation
  • Caffeine consumption
  • Coffee intake


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