Does bilayered extracellular matrix technology hasten wound healing in venous stasis ulcers? A retrospective study

Ira Lown, Tolga Kurt, Hai Tran, Mike Wayne, Cesar Santiago, Michael Cioroiu, Robert Grossi

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The clinical management of venous ulcers is debatable; however, a better understanding of the physiology has led to development of new treatment modalities. At the authors' center, bilayered extracellular matrix (ECM) technology (OASIS® Wound Matrix, Healthpoint, Ltd., Fort Worth, Tex) has been used to treat various lower-extremity wounds. In this retrospective study, the authors attempted to determine if ECM with a classic Unna boot method of compression was more effective at healing venous stasis ulcers than traditional Unna compression dressing supplemented by a wound drainage controlling agent alone. Thirty-three randomized outpatients diagnosed with venous insufficiency and venous leg ulcers were recruited to the study. The patients were divided into 2 groups based on type of dressing applied. Group A was treated with the commercially available ECM and application of a classic Unna boot method of compression. Group B was treated with the classic Unna boot method. The complete healing rates were found to be 76.56% (13/18) in Group A and 74.46% (11/15) in Group B at the end of 12 weeks. The tri-weekly wound surface reduction (cm 2) was 2.78±0.32 for Group A and 2.34±0.21 for Group B. The comparison of both groups according to the complete healing rates showed no significant difference (p>0.05).

Original languageEnglish
Pages (from-to)27-31
Number of pages5
JournalWounds
Volume17
Issue number2
StatePublished - Feb 2005
Externally publishedYes

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