Do Serum Creatinine Levels Show Clinically Significant Fluctuations on Serial Determinations on the Siemens Advia 1800 Analyzer?

Daniel Levitan, Aaron E. Harper, Yi Sun, Jose V. Scarpa Carniello, Amir Momeni, Joshua Kagan, Herol Alexis, Ikram Eid, Loretta Harris, Barbara Marshal, Edlira Tafani, Matthew Pincus

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: The goal of this work was to determine whether there are clinically significant fluctuations in the level of serum creatinine on serial determinations, especially in the borderline range (1.1–1.3 mg/dl), after specimen storage. Methods: Sixty-one serum samples were analyzed. They were divided into three categories based on the initial serum creatinine measurement: low (≤1.0 mg/dl), borderline (1.1–1.3 mg/dl), and high (≥1.4 mg/dl). The specimens were stored at 4°C and run on the Siemens Advia 1800 chemistry analyzer on days 1, 3, and 11. Results: Statistical comparisons of the three groups were made using the unpaired t-test, yielding a two-tailed P-value for each group comparison. The P-values ranged from 0.0829 to 0.3892, indicating no statistically significant difference between the standard deviations of each group. Conclusions: Mild-to-moderate fluctuations in precision occur in successive serum creatinine determinations. The overwhelming majority of these fluctuations should not affect clinical decision making.

Original languageEnglish
Article numbere22012
JournalJournal of Clinical Laboratory Analysis
Volume31
Issue number1
DOIs
StatePublished - 1 Jan 2017
Externally publishedYes

Keywords

  • Siemens Advia 1800 analyzer
  • creatinine
  • reproducibility
  • serum
  • storage

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