Do physiological roles foster persistance of drug/multidrug-efflux transporters? A case study

Terry A. Krulwich, Oded Lewinson, Etana Padan, Eitan Bibi

Research output: Contribution to journalArticlepeer-review

82 Scopus citations

Abstract

Drug and multidrug resistance have greatly compromised the compounds that were once the mainstays of antibiotic therapy. This resistance often persists despite reductions in the use of antibiotics, indicating that the proteins encoded by antibiotic-resistance genes have alternative physiological roles that can foster such persistence in the absence of selective pressure by antibiotics. The recent observations that Tet(L), a tetracycline-efflux transporter, and MdfA, a multidrug-efflux transporter, both confer alkali tolerance offer a striking case study in support of this hypothesis.

Original languageEnglish
Pages (from-to)566-572
Number of pages7
JournalNature Reviews Microbiology
Volume3
Issue number7
DOIs
StatePublished - Jul 2005

Fingerprint

Dive into the research topics of 'Do physiological roles foster persistance of drug/multidrug-efflux transporters? A case study'. Together they form a unique fingerprint.

Cite this