Do inducers of apoptosis trigger caspase-independent cell death?

Jerry E. Chipuk, Douglas R. Green

Research output: Contribution to journalReview articlepeer-review

282 Scopus citations


Apoptotic cell death is mediated by molecular pathways that culminate in the activation of a family of cysteine proteases, known as the caspases, which orchestrate the dismantling and clearance of the dying cell. However, mounting evidence indicates that a cell that has been treated with an apoptotic inducer can also initiate a suicide programme that does not rely on caspase activation. Here, we present recent findings and discuss the physiological relevance of caspase-independent cell death.

Original languageEnglish
Pages (from-to)268-275
Number of pages8
JournalNature Reviews Molecular Cell Biology
Issue number3
StatePublished - Mar 2005
Externally publishedYes


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