Do GM1 antibodies induce demyelination?

Dale J. Lange, Werner Trojaborg

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


We review clinical, neurophysiological, immunological, and experimental data concerning multifocal motor neuropathy (MMN), a newly recognized disorder that mimics MND. It is separated from MND by the presence of multifocal conduction block (CB) demonstrated electrophysiologically, and in some instances by the association of high liters of GM1 antibodies. The possible immunopathogenetic effect of GM1 antibodies is discussed. However, 70% of patients with MMNCB do not have elevated titers of GM1 antibodies, but may respond nevertheless to immunosuppressive treatment. Thus, so far unrecognized antibodies may react against some other epitopes in the paranodal region than those attacked by GM1 antibodies to cause CB. © 1994 John Wiley & Sons, Inc.

Original languageEnglish
Pages (from-to)105-107
Number of pages3
JournalMuscle and Nerve
Issue number1
StatePublished - Jan 1994
Externally publishedYes


  • GM antibodies
  • conduction block
  • motor neuron disease


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