Do endorphins mediate placebo analgesia? A critical commentary on one of the seminal papers

Gerben Ter Riet; Anton J.M. De Craen; Anton De Boer; Alphons G.H. Kessels

Do endorphins mediate placebo analgesia? A critical commentary on one of the seminal papers

Gerben Ter Riet, Anton J.M. De Craen, Anton De Boer, Alphons G.H. Kessels

Research output: Contribution to journal › Review article › peer-review

Abstract

There are only few experimental studies that assess the hypothesis that placebo analgesia is mediated by endogenous opioids. One of these studies [Grevert P, Albert LH, Goldstein A: Partial antagonism of placebo analgesia by naloxone. Pain 1983;16:129-143] had a rather complicated design and data presentation. In this commentary we attempt to clarify the experimental design of that study. Based on a clearer understanding of the study procedures and data analysis we propose some alternative interpretations of the results.

Original language	English
Pages (from-to)	12-14
Number of pages	3
Journal	Forschende Komplementarmedizin und Klassische Naturheilkunde
Volume	5
Issue number	SUPPL.
State	Published - 1998
Externally published	Yes

Keywords

Analgesia
Double-blind method
Endorphin antagonists and inhibitors
Placebos
Random allocation

Cite this

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title = "Do endorphins mediate placebo analgesia? A critical commentary on one of the seminal papers",

abstract = "There are only few experimental studies that assess the hypothesis that placebo analgesia is mediated by endogenous opioids. One of these studies [Grevert P, Albert LH, Goldstein A: Partial antagonism of placebo analgesia by naloxone. Pain 1983;16:129-143] had a rather complicated design and data presentation. In this commentary we attempt to clarify the experimental design of that study. Based on a clearer understanding of the study procedures and data analysis we propose some alternative interpretations of the results.",

keywords = "Analgesia, Double-blind method, Endorphin antagonists and inhibitors, Placebos, Random allocation",

author = "{Ter Riet}, Gerben and {De Craen}, {Anton J.M.} and {De Boer}, Anton and Kessels, {Alphons G.H.}",

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AU - De Boer, Anton

AU - Kessels, Alphons G.H.

PY - 1998

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N2 - There are only few experimental studies that assess the hypothesis that placebo analgesia is mediated by endogenous opioids. One of these studies [Grevert P, Albert LH, Goldstein A: Partial antagonism of placebo analgesia by naloxone. Pain 1983;16:129-143] had a rather complicated design and data presentation. In this commentary we attempt to clarify the experimental design of that study. Based on a clearer understanding of the study procedures and data analysis we propose some alternative interpretations of the results.

AB - There are only few experimental studies that assess the hypothesis that placebo analgesia is mediated by endogenous opioids. One of these studies [Grevert P, Albert LH, Goldstein A: Partial antagonism of placebo analgesia by naloxone. Pain 1983;16:129-143] had a rather complicated design and data presentation. In this commentary we attempt to clarify the experimental design of that study. Based on a clearer understanding of the study procedures and data analysis we propose some alternative interpretations of the results.

KW - Analgesia

KW - Double-blind method

KW - Endorphin antagonists and inhibitors

KW - Placebos

KW - Random allocation

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M3 - Review article

AN - SCOPUS:2742551983

SN - 1424-7364

VL - 5

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JO - Forschende Komplementarmedizin und Klassische Naturheilkunde

JF - Forschende Komplementarmedizin und Klassische Naturheilkunde

IS - SUPPL.

ER -

Do endorphins mediate placebo analgesia? A critical commentary on one of the seminal papers

Abstract

Keywords

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