TY - JOUR
T1 - Do elevated TSH levels predict early pregnancy loss in ART patients?
AU - Gingold, Julian A.
AU - Zafman, Kelly
AU - Rodriguez-Purata, Jorge
AU - Whitehouse, Michael C.
AU - Lee, Joseph A.
AU - Sandler, Benjamin
AU - Copperman, Alan B.
N1 - Publisher Copyright:
© 2016 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Introduction: The upper limit of normal TSH has been revised from 5 mIU/L to 2.5 mIU/L. We sought to evaluate IVF patients and the association between abnormal TSH and early pregnancy loss. Methods: A retrospective study of patients who had TSH levels measured within the 2 weeks prior to their fresh autologous IVF cycles (2002–2014). Cohorts were stratified by oocyte age (<35, [35–38), [38–41), [41–43) and ≥43 years), and TSH level [(0–0.5], (0.5–2.5], (2.5–5], and (5–23) mIU/L]. Patients were followed until pregnancy loss or delivery. Model was assessed by chi-square of ANOVA with significance at p < 0.05. Results: TSH was abnormally elevated (>5 mIU/L), mildly elevated ((2.5–5] mIU/L) or suppressed (≤0.5 mIU/L) in 46, 317 and 65 of the 1201 total cycles, respectively. Treatment resulted in 630 pregnancies, 524 clinical pregnancies and 409 deliveries. Pregnancy loss rates were increased in patients ≥38 yo (p < 0.001) but not [35–38) yo (p = 0.40) compared with those <35 yo. Early pregnancy loss rate was not associated with TSH level (p > 0.30) compared with euthyroid patients after adjusting for oocyte age. Conclusion: Early pregnancy loss rate in IVF patients appears to have no relation to recent TSH levels.
AB - Introduction: The upper limit of normal TSH has been revised from 5 mIU/L to 2.5 mIU/L. We sought to evaluate IVF patients and the association between abnormal TSH and early pregnancy loss. Methods: A retrospective study of patients who had TSH levels measured within the 2 weeks prior to their fresh autologous IVF cycles (2002–2014). Cohorts were stratified by oocyte age (<35, [35–38), [38–41), [41–43) and ≥43 years), and TSH level [(0–0.5], (0.5–2.5], (2.5–5], and (5–23) mIU/L]. Patients were followed until pregnancy loss or delivery. Model was assessed by chi-square of ANOVA with significance at p < 0.05. Results: TSH was abnormally elevated (>5 mIU/L), mildly elevated ((2.5–5] mIU/L) or suppressed (≤0.5 mIU/L) in 46, 317 and 65 of the 1201 total cycles, respectively. Treatment resulted in 630 pregnancies, 524 clinical pregnancies and 409 deliveries. Pregnancy loss rates were increased in patients ≥38 yo (p < 0.001) but not [35–38) yo (p = 0.40) compared with those <35 yo. Early pregnancy loss rate was not associated with TSH level (p > 0.30) compared with euthyroid patients after adjusting for oocyte age. Conclusion: Early pregnancy loss rate in IVF patients appears to have no relation to recent TSH levels.
KW - Early pregnancy loss
KW - euthyroid
KW - in vitro fertilization
KW - subclinical hypothyroidism
KW - thyroid stimulating hormone
UR - http://www.scopus.com/inward/record.url?scp=84978532578&partnerID=8YFLogxK
U2 - 10.1080/09513590.2016.1200553
DO - 10.1080/09513590.2016.1200553
M3 - Article
C2 - 27426225
AN - SCOPUS:84978532578
SN - 0951-3590
VL - 32
SP - 973
EP - 976
JO - Gynecological Endocrinology
JF - Gynecological Endocrinology
IS - 12
ER -