DNMT3A overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults

Margaret A. Ferris; Amanda M. Smith; Sharon E. Heath; Eric J. Duncavage; Matthew Oberley; David Freyer; Robert Wynn; Sofia Douzgou; John M. Maris; Anne F. Reilly; Melinda D. Wu; Florence Choo; Roel B. Fiets; Saskia Koene; David H. Spencer; Christopher A. Miller; Marwan Shinawi; Timothy J. Ley

doi:10.1182/blood.2021014052

DNMT3A overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults

Margaret A. Ferris, Amanda M. Smith, Sharon E. Heath, Eric J. Duncavage, Matthew Oberley, David Freyer, Robert Wynn, Sofia Douzgou, John M. Maris, Anne F. Reilly, Melinda D. Wu, Florence Choo, Roel B. Fiets, Saskia Koene, David H. Spencer, Christopher A. Miller, Marwan Shinawi, Timothy J. Ley

Research output: Contribution to journal › Letter › peer-review

12 Scopus citations

Original language	English
Pages (from-to)	461-464
Number of pages	4
Journal	Blood
Volume	139
Issue number	3
DOIs	https://doi.org/10.1182/blood.2021014052
State	Published - 20 Jan 2022
Externally published	Yes

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10.1182/blood.2021014052

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Ferris, M. A., Smith, A. M., Heath, S. E., Duncavage, E. J., Oberley, M., Freyer, D., Wynn, R., Douzgou, S., Maris, J. M., Reilly, A. F., Wu, M. D., Choo, F., Fiets, R. B., Koene, S., Spencer, D. H., Miller, C. A., Shinawi, M., & Ley, T. J. (2022). DNMT3A overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults. Blood, 139(3), 461-464. https://doi.org/10.1182/blood.2021014052

@article{6d22588a46d2437d85a40c779de29bdd,

title = "DNMT3A overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults",

author = "Ferris, {Margaret A.} and Smith, {Amanda M.} and Heath, {Sharon E.} and Duncavage, {Eric J.} and Matthew Oberley and David Freyer and Robert Wynn and Sofia Douzgou and Maris, {John M.} and Reilly, {Anne F.} and Wu, {Melinda D.} and Florence Choo and Fiets, {Roel B.} and Saskia Koene and Spencer, {David H.} and Miller, {Christopher A.} and Marwan Shinawi and Ley, {Timothy J.}",

note = "Funding Information: This work was supported by an Alex's Lemonade Stand Foundation Young Investigator Award (M.A.F.), the National Institutes of Health (NIH), Eunice Kennedy Shriver National Institute of Child Health and Human Development grant 5K12HD07622408 (M.A.F.), ASH Fellow to Faculty Award (A.M.S.), NIH, National Cancer Institute grants R35 CA220500 (J.M.M.), NCI R50 CA211782 (Miller), PO1CA101937, and NCI R35CA197561, and the Barnes Jewish Hospital Foundation (T.J.L.). Funding Information: The authors thank the Tatton-Brown-Rahman Syndrome (TBRS) Community, and especially Jill Kiernan and Kerry Grens, for help in identifying the cases, and the patients and families themselves for their participation. The authors also thank all referring physicians for providing records and obtaining blood and bone marrow samples for the study. This work was supported by an Alex's Lemonade Stand Foundation Young Investigator Award (M.A.F.), the National Institutes of Health (NIH), Eunice Kennedy Shriver National Institute of Child Health and Human Development grant 5K12HD07622408 (M.A.F.), ASH Fellow to Faculty Award (A.M.S.), NIH, National Cancer Institute grants R35 CA220500 (J.M.M.), NCI R50 CA211782 (Miller), PO1CA101937, and NCI R35CA197561, and the Barnes Jewish Hospital Foundation (T.J.L.).",

year = "2022",

month = jan,

day = "20",

doi = "10.1182/blood.2021014052",

language = "English",

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Ferris, MA, Smith, AM, Heath, SE, Duncavage, EJ, Oberley, M, Freyer, D, Wynn, R, Douzgou, S, Maris, JM, Reilly, AF, Wu, MD, Choo, F, Fiets, RB, Koene, S, Spencer, DH, Miller, CA, Shinawi, M & Ley, TJ 2022, 'DNMT3A overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults', Blood, vol. 139, no. 3, pp. 461-464. https://doi.org/10.1182/blood.2021014052

TY - JOUR

T1 - DNMT3A overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults

AU - Ferris, Margaret A.

AU - Smith, Amanda M.

AU - Heath, Sharon E.

AU - Duncavage, Eric J.

AU - Oberley, Matthew

AU - Freyer, David

AU - Wynn, Robert

AU - Douzgou, Sofia

AU - Maris, John M.

AU - Reilly, Anne F.

AU - Wu, Melinda D.

AU - Choo, Florence

AU - Fiets, Roel B.

AU - Koene, Saskia

AU - Spencer, David H.

AU - Miller, Christopher A.

AU - Shinawi, Marwan

AU - Ley, Timothy J.

N1 - Funding Information: This work was supported by an Alex's Lemonade Stand Foundation Young Investigator Award (M.A.F.), the National Institutes of Health (NIH), Eunice Kennedy Shriver National Institute of Child Health and Human Development grant 5K12HD07622408 (M.A.F.), ASH Fellow to Faculty Award (A.M.S.), NIH, National Cancer Institute grants R35 CA220500 (J.M.M.), NCI R50 CA211782 (Miller), PO1CA101937, and NCI R35CA197561, and the Barnes Jewish Hospital Foundation (T.J.L.). Funding Information: The authors thank the Tatton-Brown-Rahman Syndrome (TBRS) Community, and especially Jill Kiernan and Kerry Grens, for help in identifying the cases, and the patients and families themselves for their participation. The authors also thank all referring physicians for providing records and obtaining blood and bone marrow samples for the study. This work was supported by an Alex's Lemonade Stand Foundation Young Investigator Award (M.A.F.), the National Institutes of Health (NIH), Eunice Kennedy Shriver National Institute of Child Health and Human Development grant 5K12HD07622408 (M.A.F.), ASH Fellow to Faculty Award (A.M.S.), NIH, National Cancer Institute grants R35 CA220500 (J.M.M.), NCI R50 CA211782 (Miller), PO1CA101937, and NCI R35CA197561, and the Barnes Jewish Hospital Foundation (T.J.L.).

PY - 2022/1/20

Y1 - 2022/1/20

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U2 - 10.1182/blood.2021014052

DO - 10.1182/blood.2021014052

M3 - Letter

C2 - 34788385

AN - SCOPUS:85123009053

SN - 0006-4971

VL - 139

SP - 461

EP - 464

JO - Blood

JF - Blood

IS - 3

ER -