DNMT3A mutations in acute myeloid leukemia

Mrinal Y. Shah; Jonathan D. Licht

doi:10.1038/ng0411-289

DNMT3A mutations in acute myeloid leukemia

Mrinal Y. Shah, Jonathan D. Licht

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

New studies reveal that 20% of individuals with acute myeloid leukemia harbor somatic mutations in DNMT3A (encoding DNA methyltransferase 3A). Although these leukemias have some gene expression and DNA methylation changes, a direct link between mutant DNMT3A, epigenetic changes and pathogenesis remains to be established.

Original language	English
Pages (from-to)	289-290
Number of pages	2
Journal	Nature Genetics
Volume	43
Issue number	4
DOIs	https://doi.org/10.1038/ng0411-289
State	Published - Feb 2011
Externally published	Yes

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title = "DNMT3A mutations in acute myeloid leukemia",

abstract = "New studies reveal that 20\% of individuals with acute myeloid leukemia harbor somatic mutations in DNMT3A (encoding DNA methyltransferase 3A). Although these leukemias have some gene expression and DNA methylation changes, a direct link between mutant DNMT3A, epigenetic changes and pathogenesis remains to be established.",

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AB - New studies reveal that 20% of individuals with acute myeloid leukemia harbor somatic mutations in DNMT3A (encoding DNA methyltransferase 3A). Although these leukemias have some gene expression and DNA methylation changes, a direct link between mutant DNMT3A, epigenetic changes and pathogenesis remains to be established.

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DNMT3A mutations in acute myeloid leukemia

Abstract

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