TY - JOUR
T1 - DNAM-1 expression marks an alternative program of NK cell maturation
AU - Martinet, Ludovic
AU - Ferrari De Andrade, Lucas
AU - Guillerey, Camille
AU - Lee, Jason S.
AU - Liu, Jing
AU - Souza-Fonseca-Guimaraes, Fernando
AU - Hutchinson, Dana S.
AU - Kolesnik, Tatiana B.
AU - Nicholson, Sandra E.
AU - Huntington, Nicholas D.
AU - Smyth, Mark J.
N1 - Publisher Copyright:
© 2015 The Authors.
PY - 2015/4/7
Y1 - 2015/4/7
N2 - Natural killer (NK) cells comprise a heterogeneous population of cells important for pathogen defense and cancer surveillance. However, the functional significance of this diversity is not fully understood. Here, we demonstrate through transcriptional profiling andfunctional studies that the activating receptor DNAM-1 (CD226) identifies two distinct NK cell functional subsets: DNAM-1+ and DNAM-1- NK cells. DNAM-1+ NK cells produce high levels of inflammatory cytokines, have enhanced interleukin 15 signaling, and proliferate vigorously. By contrast, DNAM-1- NK cells that differentiate from DNAM-1+ NK cells have greater expression of NK-cell-receptor-related genes and are higher producers of MIP1 chemokines. Collectively, our data reveal the existence of a functional program of NK cell maturation marked by DNAM-1 expression.
AB - Natural killer (NK) cells comprise a heterogeneous population of cells important for pathogen defense and cancer surveillance. However, the functional significance of this diversity is not fully understood. Here, we demonstrate through transcriptional profiling andfunctional studies that the activating receptor DNAM-1 (CD226) identifies two distinct NK cell functional subsets: DNAM-1+ and DNAM-1- NK cells. DNAM-1+ NK cells produce high levels of inflammatory cytokines, have enhanced interleukin 15 signaling, and proliferate vigorously. By contrast, DNAM-1- NK cells that differentiate from DNAM-1+ NK cells have greater expression of NK-cell-receptor-related genes and are higher producers of MIP1 chemokines. Collectively, our data reveal the existence of a functional program of NK cell maturation marked by DNAM-1 expression.
UR - http://www.scopus.com/inward/record.url?scp=84927691776&partnerID=8YFLogxK
U2 - 10.1016/j.celrep.2015.03.006
DO - 10.1016/j.celrep.2015.03.006
M3 - Article
C2 - 25818301
AN - SCOPUS:84927691776
SN - 2211-1247
VL - 11
SP - 85
EP - 97
JO - Cell Reports
JF - Cell Reports
IS - 1
ER -