DNA sensing in senescence

Marina Ruiz De Galarreta; Amaia Lujambio

doi:10.1038/ncb3603

DNA sensing in senescence

Marina Ruiz De Galarreta
, Amaia Lujambio

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Cellular senescence, a cell-autonomous growth arrest program, also executes pleiotropic non-cell-autonomous activities through the senescence-associated secretory phenotype (SASP). The innate cGAS-STING DNA-sensing pathway is now shown to regulate senescence by recognizing cytosolic DNA and inducing SASP factors, uncovering an unexpected link between these two previously unrelated pathways.

Original language	English
Pages (from-to)	1008-1009
Number of pages	2
Journal	Nature Cell Biology
Volume	19
Issue number	9
DOIs	https://doi.org/10.1038/ncb3603
State	Published - 1 Sep 2017

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title = "DNA sensing in senescence",

abstract = "Cellular senescence, a cell-autonomous growth arrest program, also executes pleiotropic non-cell-autonomous activities through the senescence-associated secretory phenotype (SASP). The innate cGAS-STING DNA-sensing pathway is now shown to regulate senescence by recognizing cytosolic DNA and inducing SASP factors, uncovering an unexpected link between these two previously unrelated pathways.",

author = "\{De Galarreta\}, \{Marina Ruiz\} and Amaia Lujambio",

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AU - De Galarreta, Marina Ruiz

AU - Lujambio, Amaia

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Cellular senescence, a cell-autonomous growth arrest program, also executes pleiotropic non-cell-autonomous activities through the senescence-associated secretory phenotype (SASP). The innate cGAS-STING DNA-sensing pathway is now shown to regulate senescence by recognizing cytosolic DNA and inducing SASP factors, uncovering an unexpected link between these two previously unrelated pathways.

AB - Cellular senescence, a cell-autonomous growth arrest program, also executes pleiotropic non-cell-autonomous activities through the senescence-associated secretory phenotype (SASP). The innate cGAS-STING DNA-sensing pathway is now shown to regulate senescence by recognizing cytosolic DNA and inducing SASP factors, uncovering an unexpected link between these two previously unrelated pathways.

UR - https://www.scopus.com/pages/publications/85028682925

U2 - 10.1038/ncb3603

DO - 10.1038/ncb3603

M3 - Review article

C2 - 28855731

AN - SCOPUS:85028682925

SN - 1465-7392

VL - 19

SP - 1008

EP - 1009

JO - Nature Cell Biology

JF - Nature Cell Biology

IS - 9

ER -

DNA sensing in senescence

Abstract

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