DNA-polymorphism of type I collagen gene detected with Bgl II in the genetically isolated finnish population

Hannele Ahti; Aarno Palotie; Leena Peltonen; Francesco Ramirez

doi:10.1007/BF00273846

DNA-polymorphism of type I collagen gene detected with Bgl II in the genetically isolated finnish population

Hannele Ahti, Aarno Palotie, Leena Peltonen, Francesco Ramirez

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Abstract

The pro α 2(I) collagen gene has been screened for Bgl II restriction fragment length polymorphisms (RFLPs) in the Finnish population which has a long background of genetic isolation. As genetically isolated populations tend to demonstrate deviations in the degree of heterozygosity, the RFLP markers described in more heterogeneous populations can not be utilized as such in the former. This proved to be the case with Bgl II polymorphism within the pro α 2(I) collagen gene, the gene involved in different disorders of connective tissue. This report describes the presence of three new RFLP-loci and the absence of one RFLP-locus, which had been earlier reported from a population with a genetic background remote from the population studied here.

Original language	English
Pages (from-to)	79-80
Number of pages	2
Journal	Human Genetics
Volume	75
Issue number	1
DOIs	https://doi.org/10.1007/BF00273846
State	Published - Jan 1987
Externally published	Yes

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title = "DNA-polymorphism of type I collagen gene detected with Bgl II in the genetically isolated finnish population",

abstract = "The pro α 2(I) collagen gene has been screened for Bgl II restriction fragment length polymorphisms (RFLPs) in the Finnish population which has a long background of genetic isolation. As genetically isolated populations tend to demonstrate deviations in the degree of heterozygosity, the RFLP markers described in more heterogeneous populations can not be utilized as such in the former. This proved to be the case with Bgl II polymorphism within the pro α 2(I) collagen gene, the gene involved in different disorders of connective tissue. This report describes the presence of three new RFLP-loci and the absence of one RFLP-locus, which had been earlier reported from a population with a genetic background remote from the population studied here.",

author = "Hannele Ahti and Aarno Palotie and Leena Peltonen and Francesco Ramirez",

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AU - Ahti, Hannele

AU - Palotie, Aarno

AU - Peltonen, Leena

AU - Ramirez, Francesco

PY - 1987/1

Y1 - 1987/1

N2 - The pro α 2(I) collagen gene has been screened for Bgl II restriction fragment length polymorphisms (RFLPs) in the Finnish population which has a long background of genetic isolation. As genetically isolated populations tend to demonstrate deviations in the degree of heterozygosity, the RFLP markers described in more heterogeneous populations can not be utilized as such in the former. This proved to be the case with Bgl II polymorphism within the pro α 2(I) collagen gene, the gene involved in different disorders of connective tissue. This report describes the presence of three new RFLP-loci and the absence of one RFLP-locus, which had been earlier reported from a population with a genetic background remote from the population studied here.

AB - The pro α 2(I) collagen gene has been screened for Bgl II restriction fragment length polymorphisms (RFLPs) in the Finnish population which has a long background of genetic isolation. As genetically isolated populations tend to demonstrate deviations in the degree of heterozygosity, the RFLP markers described in more heterogeneous populations can not be utilized as such in the former. This proved to be the case with Bgl II polymorphism within the pro α 2(I) collagen gene, the gene involved in different disorders of connective tissue. This report describes the presence of three new RFLP-loci and the absence of one RFLP-locus, which had been earlier reported from a population with a genetic background remote from the population studied here.

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JO - Human Genetics

JF - Human Genetics

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DNA-polymorphism of type I collagen gene detected with Bgl II in the genetically isolated finnish population

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