DNA ploidy of fibrolamellar hepatocellular carcinoma by image analysis

Giulia Orsatti; Pietra D. Greenberg; Donald B. Rolfes; Kamal G. Ishak; Fiorenzo Paronetto

doi:10.1016/0046-8177(94)90015-9

DNA ploidy of fibrolamellar hepatocellular carcinoma by image analysis

Giulia Orsatti, Pietra D. Greenberg, Donald B. Rolfes, Kamal G. Ishak, Fiorenzo Paronetto

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Abstract

Twelve cases of fibrolamellar hepatocellular carcinoma (FLC) were evaluated for DNA ploidy by means of image analysis of Feulgenstained tissue sections. All of the tumors showed a nondiploid DNA distribution (six aneuploid and six tetraploid); no diploid pattern was found. The nuclear area of the tumors (53.8 μm² ± 18.0; mean ± standard deviation) was significantly larger than that of the surrounding noncancerous livers (33.2 ± 4.7; P < .0001). These findings suggest that DNA content in fibrolamellar carcinoma (FLC) is not directly related to the clinical behavior and that other factors may be responsible for the better prognosis of this variant of HCC.

Original language	English
Pages (from-to)	936-939
Number of pages	4
Journal	Human Pathology
Volume	25
Issue number	9
DOIs	https://doi.org/10.1016/0046-8177(94)90015-9
State	Published - Sep 1994

Keywords

DNA ploidy
fibrolamellar carcinoma
hepatocellular carcinoma
nuclear DNA content

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title = "DNA ploidy of fibrolamellar hepatocellular carcinoma by image analysis",

abstract = "Twelve cases of fibrolamellar hepatocellular carcinoma (FLC) were evaluated for DNA ploidy by means of image analysis of Feulgenstained tissue sections. All of the tumors showed a nondiploid DNA distribution (six aneuploid and six tetraploid); no diploid pattern was found. The nuclear area of the tumors (53.8 μm2 ± 18.0; mean ± standard deviation) was significantly larger than that of the surrounding noncancerous livers (33.2 ± 4.7; P < .0001). These findings suggest that DNA content in fibrolamellar carcinoma (FLC) is not directly related to the clinical behavior and that other factors may be responsible for the better prognosis of this variant of HCC.",

keywords = "DNA ploidy, fibrolamellar carcinoma, hepatocellular carcinoma, nuclear DNA content",

author = "Giulia Orsatti and Greenberg, {Pietra D.} and Rolfes, {Donald B.} and Ishak, {Kamal G.} and Fiorenzo Paronetto",

note = "Funding Information: Supported in part by the Department of Veterans Affairs, Washington, DC.",

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doi = "10.1016/0046-8177(94)90015-9",

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T1 - DNA ploidy of fibrolamellar hepatocellular carcinoma by image analysis

AU - Orsatti, Giulia

AU - Greenberg, Pietra D.

AU - Rolfes, Donald B.

AU - Ishak, Kamal G.

AU - Paronetto, Fiorenzo

N1 - Funding Information: Supported in part by the Department of Veterans Affairs, Washington, DC.

PY - 1994/9

Y1 - 1994/9

N2 - Twelve cases of fibrolamellar hepatocellular carcinoma (FLC) were evaluated for DNA ploidy by means of image analysis of Feulgenstained tissue sections. All of the tumors showed a nondiploid DNA distribution (six aneuploid and six tetraploid); no diploid pattern was found. The nuclear area of the tumors (53.8 μm2 ± 18.0; mean ± standard deviation) was significantly larger than that of the surrounding noncancerous livers (33.2 ± 4.7; P < .0001). These findings suggest that DNA content in fibrolamellar carcinoma (FLC) is not directly related to the clinical behavior and that other factors may be responsible for the better prognosis of this variant of HCC.

AB - Twelve cases of fibrolamellar hepatocellular carcinoma (FLC) were evaluated for DNA ploidy by means of image analysis of Feulgenstained tissue sections. All of the tumors showed a nondiploid DNA distribution (six aneuploid and six tetraploid); no diploid pattern was found. The nuclear area of the tumors (53.8 μm2 ± 18.0; mean ± standard deviation) was significantly larger than that of the surrounding noncancerous livers (33.2 ± 4.7; P < .0001). These findings suggest that DNA content in fibrolamellar carcinoma (FLC) is not directly related to the clinical behavior and that other factors may be responsible for the better prognosis of this variant of HCC.

KW - DNA ploidy

KW - fibrolamellar carcinoma

KW - hepatocellular carcinoma

KW - nuclear DNA content

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JO - Human Pathology

JF - Human Pathology

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ER -

DNA ploidy of fibrolamellar hepatocellular carcinoma by image analysis

Abstract

Keywords

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