DNA ploidy of colorectal cancer and synchronous polyps in polyposis coli

Felice Miller, Tomas M. Heimann, Arnold Szporn, Giorgio Martinelli, Robert J. Kurtz, Thomas M. Fasy

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Sixteen patients with polyposis coli and cancer were studied retrospectively to determine the incidence of DNA ploidy abnormalities in the tumors and synchronous polyps. Six patients (37 percent) had nondiploid tumors. Nondiploid tumors were more likely to be advanced and had a significantly worse prognosis (17 percentvs. 76 percent 5-year survival;P<0.01). Only 4 of 20 polyps studied were nondiploid. There was no association between tumor and polyp ploidy. All nondiploid polyps were found in patients with synchronous diploid cancers. Patients with nondiploid polyps were more likely to be older and have more advanced tumors than those with diploid polyps. DNA ploidy abnormalities seem to occur with the same frequency in polyposis coli as in the nonpolyposis population, and tumor ploidy correlates with prognosis

Original languageEnglish
Pages (from-to)1103-1108
Number of pages6
JournalDiseases of the Colon and Rectum
Issue number12
StatePublished - Dec 1991
Externally publishedYes


  • Aneuploidy
  • Cancer
  • DNA ploidy
  • Familial polyposis
  • Flow cytometry
  • Multiple polyposis
  • Polyposis coli
  • Polyps


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