DNA ploidy of colorectal cancer and synchronous polyps in polyposis coli

Felice Miller; Tomas M. Heimann; Arnold Szporn; Giorgio Martinelli; Robert J. Kurtz; Thomas M. Fasy

doi:10.1007/BF02050070

DNA ploidy of colorectal cancer and synchronous polyps in polyposis coli

Felice Miller, Tomas M. Heimann, Arnold Szporn, Giorgio Martinelli, Robert J. Kurtz, Thomas M. Fasy

Research output: Contribution to journal › Article › peer-review

Abstract

Sixteen patients with polyposis coli and cancer were studied retrospectively to determine the incidence of DNA ploidy abnormalities in the tumors and synchronous polyps. Six patients (37 percent) had nondiploid tumors. Nondiploid tumors were more likely to be advanced and had a significantly worse prognosis (17 percentvs. 76 percent 5-year survival;P<0.01). Only 4 of 20 polyps studied were nondiploid. There was no association between tumor and polyp ploidy. All nondiploid polyps were found in patients with synchronous diploid cancers. Patients with nondiploid polyps were more likely to be older and have more advanced tumors than those with diploid polyps. DNA ploidy abnormalities seem to occur with the same frequency in polyposis coli as in the nonpolyposis population, and tumor ploidy correlates with prognosis

Original language	English
Pages (from-to)	1103-1108
Number of pages	6
Journal	Diseases of the Colon and Rectum
Volume	34
Issue number	12
DOIs	https://doi.org/10.1007/BF02050070
State	Published - Dec 1991
Externally published	Yes

Keywords

Aneuploidy
Cancer
DNA ploidy
Familial polyposis
Flow cytometry
Multiple polyposis
Polyposis coli
Polyps

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10.1007/BF02050070

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title = "DNA ploidy of colorectal cancer and synchronous polyps in polyposis coli",

abstract = "Sixteen patients with polyposis coli and cancer were studied retrospectively to determine the incidence of DNA ploidy abnormalities in the tumors and synchronous polyps. Six patients (37 percent) had nondiploid tumors. Nondiploid tumors were more likely to be advanced and had a significantly worse prognosis (17 percentvs. 76 percent 5-year survival;P<0.01). Only 4 of 20 polyps studied were nondiploid. There was no association between tumor and polyp ploidy. All nondiploid polyps were found in patients with synchronous diploid cancers. Patients with nondiploid polyps were more likely to be older and have more advanced tumors than those with diploid polyps. DNA ploidy abnormalities seem to occur with the same frequency in polyposis coli as in the nonpolyposis population, and tumor ploidy correlates with prognosis",

keywords = "Aneuploidy, Cancer, DNA ploidy, Familial polyposis, Flow cytometry, Multiple polyposis, Polyposis coli, Polyps",

author = "Felice Miller and Heimann, {Tomas M.} and Arnold Szporn and Giorgio Martinelli and Kurtz, {Robert J.} and Fasy, {Thomas M.}",

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T1 - DNA ploidy of colorectal cancer and synchronous polyps in polyposis coli

AU - Miller, Felice

AU - Heimann, Tomas M.

AU - Szporn, Arnold

AU - Martinelli, Giorgio

AU - Kurtz, Robert J.

AU - Fasy, Thomas M.

PY - 1991/12

Y1 - 1991/12

N2 - Sixteen patients with polyposis coli and cancer were studied retrospectively to determine the incidence of DNA ploidy abnormalities in the tumors and synchronous polyps. Six patients (37 percent) had nondiploid tumors. Nondiploid tumors were more likely to be advanced and had a significantly worse prognosis (17 percentvs. 76 percent 5-year survival;P<0.01). Only 4 of 20 polyps studied were nondiploid. There was no association between tumor and polyp ploidy. All nondiploid polyps were found in patients with synchronous diploid cancers. Patients with nondiploid polyps were more likely to be older and have more advanced tumors than those with diploid polyps. DNA ploidy abnormalities seem to occur with the same frequency in polyposis coli as in the nonpolyposis population, and tumor ploidy correlates with prognosis

AB - Sixteen patients with polyposis coli and cancer were studied retrospectively to determine the incidence of DNA ploidy abnormalities in the tumors and synchronous polyps. Six patients (37 percent) had nondiploid tumors. Nondiploid tumors were more likely to be advanced and had a significantly worse prognosis (17 percentvs. 76 percent 5-year survival;P<0.01). Only 4 of 20 polyps studied were nondiploid. There was no association between tumor and polyp ploidy. All nondiploid polyps were found in patients with synchronous diploid cancers. Patients with nondiploid polyps were more likely to be older and have more advanced tumors than those with diploid polyps. DNA ploidy abnormalities seem to occur with the same frequency in polyposis coli as in the nonpolyposis population, and tumor ploidy correlates with prognosis

KW - Aneuploidy

KW - Cancer

KW - DNA ploidy

KW - Familial polyposis

KW - Flow cytometry

KW - Multiple polyposis

KW - Polyposis coli

KW - Polyps

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JO - Diseases of the Colon and Rectum

JF - Diseases of the Colon and Rectum

IS - 12

ER -

DNA ploidy of colorectal cancer and synchronous polyps in polyposis coli

Abstract

Keywords

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