DNA of Epstein Barr virus detected in tissue of Burkitt's lymphoma and nasopharyngeal carcinoma

M. Nonoyama, C. H. Huang, J. S. Pagano, G. Klein, S. Singh

Research output: Contribution to journalArticlepeer-review

194 Scopus citations

Abstract

The association of Epstein Barr virus (EBV) DNA with African tumors was examined by the method of hybridization with complementary RNA. 22 out of 23 biopsies of Burkitt's lymphoma and 18 out of 23 biopsies of nasopharyngeal carcinoma were found to contain EBV DNA. The number of EBV genome equivalents per cell ranged from 4 to 113. Five out of 24 other African tumors, 2 adenocarcinomas, and one each of melanoma, reticulum cell sarcoma, and carcinoma of the antrum, also contained EBV DNA.

Original languageEnglish
Pages (from-to)3265-3268
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume70
Issue number11
DOIs
StatePublished - 1973

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